Aside from acute renal failure cases, are urinary markers of glomerular and tubular function useful in clinical practice?

Acute Kidney Injury / diagnosis Biomarkers / urine Female Humans Kidney Diseases / diagnosis Male Proteinuria / diagnosis
Glomerular disease Proteinuria Tubulopathy

Journal

Clinical biochemistry
ISSN: 1873-2933
Titre abrégé: Clin Biochem
Pays: United States
ID NLM: 0133660

Informations de publication

Date de publication:
Mar 2019
Historique:
received: 28 06 2018
revised: 22 01 2019
accepted: 24 01 2019
pubmed: 28 1 2019
medline: 19 3 2019
entrez: 28 1 2019
Statut: ppublish

Résumé

The qualitative evaluation of proteinuria represents a crucial diagnostic step in clinical practice for the classification of renal diseases according to glomerular, tubulo-interstitial, mixed injury or related to monoclonal gammopathy. Combined with the quantitative evaluation, it also allows an assessment of the disease's severity and prognosis as well as the response to treatment. The development of the urine protein profile (UPP) combines specific urine protein assays on a urine spot analyzing glomerular protein markers such as albumin, transferrin and immunoglobulin G, and tubular markers such as alpha-1microglobulin and retinol binding protein, to generate a detailed quantitative and qualitative proteinuria assessment. This short overview proposes to illustrate the diagnostic and prognostic usefulness of UPP in different common clinical situations.

Identifiants

DOI: 10.1016/j.clinbiochem.2019.01.006 PMID: 30685208
pubmed: 30685208
pii: S0009-9120(17)31082-2
doi: 10.1016/j.clinbiochem.2019.01.006
pii:
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-6

Informations de copyright

Copyright © 2019 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Auteurs

Jean-Philippe Bastard (JP)

AP-HP, UF Biomarqueurs Inflammatoires et Métaboliques, Service de Biochimie et Hormonologie, Hôpital Tenon, Paris, France; Sorbonne Université, UPMC Université Paris 06, INSERM UMRS_938, CDR-Saint-Antoine, DHU i2B, IHU ICAN, Paris, France. Electronic address: jean-philippe.bastard@aphp.fr.

Soraya Fellahi (S)

AP-HP, UF Biomarqueurs Inflammatoires et Métaboliques, Service de Biochimie et Hormonologie, Hôpital Tenon, Paris, France; Sorbonne Université, UPMC Université Paris 06, INSERM UMRS_938, CDR-Saint-Antoine, DHU i2B, IHU ICAN, Paris, France.

Axel Regeniter (A)

Medica medical Laboratories, Wolfbachstrasse 17, CH-8032 Zurich, Switzerland.

Jacqueline Capeau (J)

Sorbonne Université, UPMC Université Paris 06, INSERM UMRS_938, CDR-Saint-Antoine, IHU ICAN, Paris, France.

Pierre Ronco (P)

Sorbonne Université, UPMC Université Paris 06, INSERM UMRS_1155, Paris, France.; AP-HP, Service de Néphrologie et Dialyse, Hôpital Tenon, Paris, France.

Emmanuelle Plaisier (E)

Sorbonne Université, UPMC Université Paris 06, INSERM UMRS_1155, Paris, France.; AP-HP, Service de Néphrologie et Dialyse, Hôpital Tenon, Paris, France.

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Classifications MeSH

questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Insuffisance rénale › Atteinte rénale aigüe › Aside from acute renal failure cases, are...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Aside from acute renal failure cases, are...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Aside from acute renal failure cases, are...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Aside from acute renal failure cases, are...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations urologiques › Protéinurie › Aside from acute renal failure cases, are...