Free radicals in Alzheimer's disease: Lipid peroxidation biomarkers.
Alzheimer's disease
Biomarker
Free radicals
Lipid peroxidation
Journal
Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Titre abrégé: Clin Chim Acta
Pays: Netherlands
ID NLM: 1302422
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
22
11
2018
revised:
21
01
2019
accepted:
23
01
2019
pubmed:
28
1
2019
medline:
19
3
2019
entrez:
28
1
2019
Statut:
ppublish
Résumé
Alzheimer's disease (AD), the most common form of dementia, has tremendous social and economic impact worldwide. Research has shown an association between pathologic development of AD and increased free-radical production. As such, the role of peroxidation in brain lipid damage and AD progression has received special attention. Previous studies on lipid peroxidation have improved our understanding of the unique pathophysiologic processes involved in AD. These studies have also served to identify potentially new biomarkers including lipid peroxidation metabolites for diagnosis, prognosis and therapy. Unfortunately, these putative markers have generated controversial results and further research, especially early stage AD, is clearly warranted. The aim of this paper is to review the usefulness of lipid peroxidation biomarkers in AD diagnosis and prognosis as well as monitoring disease development and therapeutic treatment thereof.
Identifiants
pubmed: 30685358
pii: S0009-8981(19)30045-2
doi: 10.1016/j.cca.2019.01.021
pii:
doi:
Substances chimiques
Biomarkers
0
Free Radicals
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
85-90Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.