Efficacy of autologous serum tears for treatment of neuropathic corneal pain.
Adult
Aged
Case-Control Studies
Cornea
/ innervation
Eye Pain
/ diagnosis
Female
Humans
Male
Microscopy, Confocal
/ methods
Middle Aged
Nerve Fibers
/ pathology
Neuralgia
/ diagnosis
Ophthalmic Nerve
/ diagnostic imaging
Ophthalmic Solutions
/ administration & dosage
Pain Management
/ methods
Pain Measurement
Plasma
Retrospective Studies
Tears
/ physiology
Autologous serum tears
Corneal allodynia
Corneal nerve regeneration
Corneal neuropathic pain
In vivo confocal microscopy
Journal
The ocular surface
ISSN: 1937-5913
Titre abrégé: Ocul Surf
Pays: United States
ID NLM: 101156063
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
31
07
2018
revised:
21
01
2019
accepted:
23
01
2019
pubmed:
28
1
2019
medline:
20
9
2020
entrez:
28
1
2019
Statut:
ppublish
Résumé
Corneal nerve damage may result in neuropathic corneal pain (NCP). Autologous serum tears (AST) have been shown to results in nerve regeneration and may help alleviate corneal pain. This study aimed to evaluate the efficacy of AST in the treatment of NCP. This was a retrospective case-control study. Sixteen patients suffering from severe NCP and no current ocular surface disease were compared to 12 controls. In vivo confocal microscopy (IVCM) (HRT3/RCM; Heidelberg Engineering GmbH, Germany) of the central corneas was performed bilaterally. Change in pain severity (scale of 0-10), corneal nerve density, tortuosity, reflectivity and presence of beading and micro-neuromas before and after treatment were recorded. All patients had severe pain, with a mean of 9.1 ± 0.2 (range 8-10). Subbasal nerves were significantly decreased before treatment as compared to controls, including total nerve length (10,935.5 ± 1264.3 vs. 24,714.4 ± 1056.2 μm/mm IVCM demonstrates underlying alterations of the subbasal corneal nerve plexus in patients suffering from debilitating NCP. AST-induced nerve regeneration is seen following treatment with AST, which correlates with improvement in patient symptoms of NCP.
Identifiants
pubmed: 30685437
pii: S1542-0124(18)30238-6
doi: 10.1016/j.jtos.2019.01.009
pmc: PMC6956846
mid: NIHMS1524043
pii:
doi:
Substances chimiques
Ophthalmic Solutions
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
532-539Subventions
Organisme : NEI NIH HHS
ID : K08 EY020575
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029602
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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