Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis.
Atopic dermatitis
T(H)1
T(H)17
T(H)2
T(H)22
aging
biomarker
filaggrin
hyperplasia
loricrin
skin
Journal
The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
24
07
2018
revised:
04
01
2019
accepted:
17
01
2019
pubmed:
28
1
2019
medline:
19
5
2020
entrez:
28
1
2019
Statut:
ppublish
Résumé
Atopic dermatitis (AD) shows differential clinical presentation in older compared with younger patients. Nevertheless, changes in the AD molecular profile with age are unknown. We sought to characterize age-related changes in the AD profile. We evaluated age-specific changes in lesional and nonlesional tissues and blood from patients with moderate-to-severe AD (n = 246) and age-matched control subjects (n = 71) using immunohistochemistry, quantitative real-time PCR, and Singulex in a cross-sectional study. Patients were analyzed by age group (18-40, 41-60, and ≥61 years). Although disease severity/SCORAD scores were similar across AD age groups (mean, approximately 60 years; P = .873), dendritic cell infiltrates (CD1b The adult AD profile varies with age. Although T
Sections du résumé
BACKGROUND
Atopic dermatitis (AD) shows differential clinical presentation in older compared with younger patients. Nevertheless, changes in the AD molecular profile with age are unknown.
OBJECTIVE
We sought to characterize age-related changes in the AD profile.
METHODS
We evaluated age-specific changes in lesional and nonlesional tissues and blood from patients with moderate-to-severe AD (n = 246) and age-matched control subjects (n = 71) using immunohistochemistry, quantitative real-time PCR, and Singulex in a cross-sectional study. Patients were analyzed by age group (18-40, 41-60, and ≥61 years).
RESULTS
Although disease severity/SCORAD scores were similar across AD age groups (mean, approximately 60 years; P = .873), dendritic cell infiltrates (CD1b
CONCLUSION
The adult AD profile varies with age. Although T
Identifiants
pubmed: 30685456
pii: S0091-6749(19)30107-1
doi: 10.1016/j.jaci.2019.01.015
pii:
doi:
Substances chimiques
Cytokines
0
FLG protein, human
0
Filaggrin Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
144-156Informations de copyright
Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.