Mitophagy links oxidative stress conditions and neurodegenerative diseases.
Alzheimer's disease
Huntington's disease
Parkinson's disease
amyotrophic lateral sclerosis
central nervous system
mitophagy
nerve regeneration
oxidative species
reactive nitrogen species
reactive oxygen species
Journal
Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
entrez:
29
1
2019
pubmed:
29
1
2019
medline:
29
1
2019
Statut:
ppublish
Résumé
Mitophagy is activated by a number of stimuli, including hypoxia, energy stress, and increased oxidative phosphorylation activity. Mitophagy is associated with oxidative stress conditions and central neurodegenerative diseases. Proper regulation of mitophagy is crucial for maintaining homeostasis; conversely, inadequate removal of mitochondria through mitophagy leads to the generation of oxidative species, including reactive oxygen species and reactive nitrogen species, resulting in various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. These diseases are most prevalent in older adults whose bodies fail to maintain proper mitophagic functions to combat oxidative species. As mitophagy is essential for normal body function, by targeting mitophagic pathways we can improve these disease conditions. The search for effective remedies to treat these disease conditions is an ongoing process, which is why more studies are needed. Additionally, more relevant studies could help establish therapeutic conditions, which are currently in high demand. In this review, we discuss how mitophagy plays a significant role in homeostasis and how its dysregulation causes neurodegeneration. We also discuss how combating oxidative species and targeting mitophagy can help treat these neurodegenerative diseases.
Identifiants
pubmed: 30688256
pii: NeuralRegenRes_2019_14_5_749_249218
doi: 10.4103/1673-5374.249218
pmc: PMC6375051
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
749-756Déclaration de conflit d'intérêts
None
Références
Front Cell Neurosci. 2018 Apr 18;12:92
pubmed: 29755319
Autophagy. 2006 Jul-Sep;2(3):234-7
pubmed: 16874061
Hum Mol Genet. 2008 Jan 15;17(2):170-8
pubmed: 17921520
Methods Mol Biol. 2008;445:119-24
pubmed: 18425446
J Biol Chem. 2009 May 15;284(20):13843-13855
pubmed: 19279012
Protein Cell. 2017 Jan;8(1):25-38
pubmed: 27757847
Nat Rev Neurosci. 2018 Jan 19;19(2):63-80
pubmed: 29348666
Adv Exp Med Biol. 2017;964:235-254
pubmed: 28315275
Front Pharmacol. 2014 Mar 05;5:37
pubmed: 24634659
BMB Rep. 2009 Jun 30;42(6):324-30
pubmed: 19558789
J Neural Transm Suppl. 2000;59:133-54
pubmed: 10961426
Biochem Biophys Res Commun. 2017 Feb 19;483(4):1187-1193
pubmed: 27416757
Oxid Med Cell Longev. 2013;2013:162152
pubmed: 23840916
Sci Rep. 2017 Mar 10;7:44373
pubmed: 28281653
Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5074-9
pubmed: 22416121
Cell Death Dis. 2015 Jan 22;6:e1617
pubmed: 25611391
Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3631-40
pubmed: 25136135
Front Aging Neurosci. 2015 May 26;7:100
pubmed: 26074815
J Biol Chem. 2011 Jun 3;286(22):19630-40
pubmed: 21454557
Autophagy. 2010 Oct;6(7):871-8
pubmed: 20798600
Biochem Biophys Res Commun. 2014 Feb 7;444(2):182-8
pubmed: 24440703
J Neuropathol Exp Neurol. 2005 Feb;64(2):113-22
pubmed: 15751225
Rejuvenation Res. 2005 Spring;8(1):3-5
pubmed: 15798367
Cell Metab. 2018 Feb 6;27(2):439-449.e5
pubmed: 29337137
Neuromolecular Med. 2014 Jun;16(2):217-30
pubmed: 24522549
Pflugers Arch. 2012 Jul;464(1):111-21
pubmed: 22615071
Nature. 2000 Nov 9;408(6809):239-47
pubmed: 11089981
J Biol Chem. 2008 Apr 18;283(16):10892-903
pubmed: 18281291
Cell. 2007 Dec 14;131(6):1149-63
pubmed: 18083104
Nat Rev Drug Discov. 2013 Sep;12(9):703-19
pubmed: 23989796
Longev Healthspan. 2014 May 01;3:6
pubmed: 24860647
Nat Rev Mol Cell Biol. 2018 Jun;19(6):349-364
pubmed: 29618831
Mol Neurobiol. 2018 Sep;55(9):7352-7365
pubmed: 29411264
Neuron. 2015 Jan 21;85(2):257-73
pubmed: 25611507
PLoS Genet. 2012;8(8):e1002918
pubmed: 22952452
Autophagy. 2014 Jul;10(7):1256-71
pubmed: 24905722
Free Radic Biol Med. 2013 Sep;62:37-46
pubmed: 23602910
Cold Spring Harb Symp Quant Biol. 2005;70:363-74
pubmed: 16869773
PLoS One. 2011 Mar 08;6(3):e16746
pubmed: 21408142
Free Radic Biol Med. 2009 Nov 15;47(10):1354-61
pubmed: 19686841
Toxicol Lett. 2018 Jan 5;282:100-108
pubmed: 29097221
Brain Res. 2015 May 14;1607:36-46
pubmed: 25301687
Redox Biol. 2013;1(1):19-23
pubmed: 23946931
Biosci Rep. 2015 Feb 25;35(1):
pubmed: 25608948
Autophagy. 2009 Oct;5(7):1037-8
pubmed: 19838079
Curr Opin Cell Biol. 2015 Apr;33:95-101
pubmed: 25697963
Neurosci Lett. 2012 Nov 21;530(2):144-9
pubmed: 23063673
J Clin Invest. 2008 Jun;118(6):2190-9
pubmed: 18497889
Nat Neurosci. 2007 May;10(5):535-7
pubmed: 17453052
Cell Stem Cell. 2016 Dec 1;19(6):709-724
pubmed: 27618216
Neurosci Lett. 2018 Jun 21;678:8-15
pubmed: 29715546
Hum Mol Genet. 2014 Mar 15;23(6):1413-24
pubmed: 24154542
Int J Mol Med. 2017 Jan;39(1):3-8
pubmed: 27959386
EMBO Rep. 2010 Jan;11(1):45-51
pubmed: 20010802
Autophagy. 2015;11(5):858-60
pubmed: 25985010
Am J Pathol. 2008 Feb;172(2):454-69
pubmed: 18187572
Cell Biochem Biophys. 2014 Nov;70(2):707-19
pubmed: 24807843
Neurosci Lett. 2019 Apr 1;697:66-71
pubmed: 29626647
Autophagy. 2007 Nov-Dec;3(6):663-6
pubmed: 17622797
J Neurochem. 2011 Jun;117(5):856-67
pubmed: 21426348
Neurosci Lett. 2014 Jun 6;570:102-7
pubmed: 24769125
Neurobiol Dis. 2011 Sep;43(3):543-51
pubmed: 21600285
Neuropathology. 2010 Apr;30(2):189-93
pubmed: 20102523
J Neuroinflammation. 2012 Jul 02;9:155
pubmed: 22747919
Dev Cell. 2012 Feb 14;22(2):320-33
pubmed: 22280891
Neurochem Int. 2018 Jul;117:174-187
pubmed: 28532681
Autophagy. 2014 Feb;10(2):376-8
pubmed: 24351649
J Cell Biol. 2018 May 7;217(5):1613-1622
pubmed: 29500189
Pharmacol Ther. 2015 Dec;156:34-43
pubmed: 26481155
Autophagy. 2012 Oct;8(10):1462-76
pubmed: 22889933
Exp Gerontol. 2014 Aug;56:147-53
pubmed: 24607515
Nat Cell Biol. 2013 Oct;15(10):1197-1205
pubmed: 24036476
Nat Neurosci. 2010 May;13(5):567-76
pubmed: 20383138
EMBO J. 2006 Aug 23;25(16):3900-11
pubmed: 16874299
Circ Res. 2012 Oct 12;111(9):1208-21
pubmed: 23065344
Cell. 2010 Jun 25;141(7):1146-58
pubmed: 20541250
EMBO Rep. 2012 Apr;13(4):378-85
pubmed: 22354088
Neurochem Int. 2017 Oct;109:202-209
pubmed: 28235551
J Biol Chem. 2007 Aug 17;282(33):23788-98
pubmed: 17537722
EMBO Rep. 2014 Aug;15(8):839-52
pubmed: 25027988
Free Radic Biol Med. 2002 Jun 1;32(11):1050-60
pubmed: 12031889