SNPs rs10224002 in PRKAG2 may disturb gene expression and consequently affect hypertension.
AMP-Activated Protein Kinases
/ genetics
Adult
Aged
Asian People
/ genetics
China
Cigarette Smoking
/ adverse effects
Coronary Artery Disease
/ genetics
Ethnicity
/ genetics
Female
Gene Expression Regulation
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Hypertension
/ genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
/ genetics
Quantitative Trait Loci
Sex Factors
Stroke
/ genetics
Gene expression
Genome-wide association study
Hypertension
PRKAG2
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
18
09
2018
accepted:
17
01
2019
pubmed:
29
1
2019
medline:
10
9
2019
entrez:
29
1
2019
Statut:
ppublish
Résumé
Genome-wide association studies have identified a large number of genetic loci for blood pressure in European populations. The associations in other populations are needed to determine. The purpose of this study was to examine the associations between the single nucleotide polymorphisms (SNPs) identified in European populations and hypertension in the Chinese Han population, and highlight the potential roles. Seven tag-SNPs were genotyped in 857 hypertension cases and 927 controls to test the associations. The intronic SNP rs10224002 (PRKAG2) which could affect DNase and regulatory motif was associated with hypertension (P = 0.024). This SNP was also found to be associated with coronary artery disease and stroke. We searched for potential functional variants by bioinformatics analysis and found various kinds of variants such as missense mutations, phosphorylation-related SNPs and SNPs that have regulatory potentials in the blood pressure loci. We performed expression quantitative trait locus (eQTL) and differential expression analyses for the identified variants and genes. eQTL analysis found that rs10224002 was associated with PRKAG2 gene expression in peripheral blood (P = 0.0016). PRKAG2 was differentially expressed between hypertension cases and controls (P = 0.0133), coronary artery disease cases and controls (P = 0.02112) and stroke cases and controls (P = 0.0059). Our study demonstrated that SNPs rs10224002 may be associated with hypertension in the Chinese Han population and PRKAG2 may play a role in the etiology of hypertension and cardiovascular diseases.
Identifiants
pubmed: 30689184
doi: 10.1007/s11033-019-04610-3
pii: 10.1007/s11033-019-04610-3
doi:
Substances chimiques
PRKAG2 protein, human
EC 2.7.11.1
AMP-Activated Protein Kinases
EC 2.7.11.31
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1617-1624Subventions
Organisme : Natural Science Foundation of China
ID : 81773508
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