Impaired immunoregulatory network of the CD4 T lymphocytes in refractory asthma.
Adult
Age of Onset
Asthma
/ diagnosis
Biomarkers
CD4-Positive T-Lymphocytes
/ immunology
CTLA-4 Antigen
/ metabolism
Cytokines
/ metabolism
Female
Flow Cytometry
Humans
Hypersensitivity, Immediate
/ immunology
Immunoglobulin E
/ immunology
Immunomodulation
Immunophenotyping
Leukocytes, Mononuclear
/ immunology
Male
Middle Aged
Respiratory Function Tests
T-Lymphocyte Subsets
/ immunology
Vitamin D
/ metabolism
CD4 T lymphocyte
asthma
refractoriness
regulatory molecules
Journal
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
ISSN: 1365-2222
Titre abrégé: Clin Exp Allergy
Pays: England
ID NLM: 8906443
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
16
07
2018
revised:
29
12
2018
accepted:
17
01
2019
pubmed:
29
1
2019
medline:
1
7
2020
entrez:
29
1
2019
Statut:
ppublish
Résumé
The immunopathogenesis of severe asthma has been associated with an inefficient regulatory response. There are a few studies about the CD4 T cells profile among individuals with severe asthma refractory to treatment. To evaluate the CD4 T lymphocyte profile from individuals with severe asthma according to their response to treatment, relating to their atopy status and age of asthma onset. We evaluated nineteen individuals with severe asthma refractory to treatment (SAR), 21 with well-controlled or partly controlled severe asthma (CSA) and 23 with mild-to-moderate asthma (MMA). Lymphocytes were obtained from PBMC, and the frequency of expression of different molecules in this population was assessed using the flow cytometry. We observed the frequency of CD4 Our data suggest that refractoriness to treatment in asthma is associated with a lower expression of distinct regulatory molecules by CD4 T cells between those who are atopic and have EOA and those who are non-atopic and have LOA. Thus, these results may contribute to the identification of new regulatory strategies to treat asthma according to their phenotypes.
Sections du résumé
BACKGROUND
The immunopathogenesis of severe asthma has been associated with an inefficient regulatory response. There are a few studies about the CD4 T cells profile among individuals with severe asthma refractory to treatment.
OBJECTIVE
To evaluate the CD4 T lymphocyte profile from individuals with severe asthma according to their response to treatment, relating to their atopy status and age of asthma onset.
METHODS
We evaluated nineteen individuals with severe asthma refractory to treatment (SAR), 21 with well-controlled or partly controlled severe asthma (CSA) and 23 with mild-to-moderate asthma (MMA). Lymphocytes were obtained from PBMC, and the frequency of expression of different molecules in this population was assessed using the flow cytometry.
RESULTS
We observed the frequency of CD4
CONCLUSION AND CLINICAL RELEVANCE
Our data suggest that refractoriness to treatment in asthma is associated with a lower expression of distinct regulatory molecules by CD4 T cells between those who are atopic and have EOA and those who are non-atopic and have LOA. Thus, these results may contribute to the identification of new regulatory strategies to treat asthma according to their phenotypes.
Substances chimiques
Biomarkers
0
CTLA-4 Antigen
0
CTLA4 protein, human
0
Cytokines
0
Vitamin D
1406-16-2
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
644-654Informations de copyright
© 2019 John Wiley & Sons Ltd.