Synthesis and antitumor activity of 2-isocamphanyl thiosemicarbazone derivatives via ROS-enhanced mitochondrial damage.
Antineoplastic Agents
/ chemical synthesis
Apoptosis
/ drug effects
Caspase 3
/ genetics
Caspase 9
/ genetics
Cell Line, Tumor
Cell Survival
/ drug effects
Gene Expression Regulation
/ drug effects
Humans
Membrane Potential, Mitochondrial
/ drug effects
Mitochondria
/ drug effects
Proto-Oncogene Proteins c-bcl-2
/ genetics
Reactive Oxygen Species
/ metabolism
Thiosemicarbazones
/ chemical synthesis
2-isocamphanyl thiosemicarbazone derivatives
antitumor activity
cell apoptosis
mitochondria
reactive oxygen species
Journal
Chemical biology & drug design
ISSN: 1747-0285
Titre abrégé: Chem Biol Drug Des
Pays: England
ID NLM: 101262549
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
24
10
2018
revised:
14
12
2018
accepted:
19
01
2019
pubmed:
29
1
2019
medline:
25
8
2020
entrez:
29
1
2019
Statut:
ppublish
Résumé
A series of novel 2-isocamphanyl thiosemicarbazone derivatives were synthesized and characterized by
Substances chimiques
Antineoplastic Agents
0
Proto-Oncogene Proteins c-bcl-2
0
Reactive Oxygen Species
0
Thiosemicarbazones
0
Caspase 3
EC 3.4.22.-
Caspase 9
EC 3.4.22.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1281-1291Informations de copyright
© 2019 John Wiley & Sons A/S.