CoCr porous scaffolds manufactured via selective laser melting in orthopedics: Topographical, mechanical, and biological characterization.
in vitro biocompatibility
biocompatibility
cobalt-chrome
implant-bone interface
mechanical properties
orthopedics
porous scaffolds
selective laser melting
trabecular lattice
Journal
Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981
Titre abrégé: J Biomed Mater Res B Appl Biomater
Pays: United States
ID NLM: 101234238
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
08
05
2018
revised:
16
11
2018
accepted:
23
12
2018
pubmed:
29
1
2019
medline:
12
8
2020
entrez:
29
1
2019
Statut:
ppublish
Résumé
Over the last decade, advances in additive manufacturing have allowed to obtain complex 3D porous lattice in materials suitable for orthopedic applications. Whereas 3D-melted titanium alloys have been extensively investigated, little is the current knowledge on the feasibility of bone-replicating CoCr porous scaffolds manufactured via selective laser melting (SLM). Moreover, the effect of topography on bone cells viability and proliferation has not been fully explored yet. Small cylindrical porous lattices were modeled from micro-CT images of human trabecular bone, and from the repetition of spherical-hollow and body-centered cubic unit cells, and manufactured via SLM from CoCr powder. Macro- and microcharacterization of the porous samples were assessed using optical microscope, micro-CT, and SEM. The scaffolds mechanical properties, measured via ISO testing, compared well with those of the human bone. Osteoblast-like cells proliferation and viability were assessed in vitro, and compared to those cultured on a standard nonporous implant-to-bone interface, showing steady increase on all geometries over time. SEM analysis confirmed the quality of cells morphology, spread, and organization on all lattices. The SLM process appeared not to alter the biocompatibility of CoCr; however, 15-100 μm irregularities and macroalterations were observed in the porous scaffolds with respect to the 3D nominal models. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2343-2353, 2019.
Substances chimiques
Alloys
0
Chromium
0R0008Q3JB
Cobalt
3G0H8C9362
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2343-2353Subventions
Organisme : Emilia-Romagna region
ID : Por Fesr 2014/2020
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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