Improving Dietary Protein Quality Reduces the Negative Effects of Physical Inactivity on Body Composition and Muscle Function.
Atrophy
Bed rest
Nutrition
Whey protein
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
ISSN: 1758-535X
Titre abrégé: J Gerontol A Biol Sci Med Sci
Pays: United States
ID NLM: 9502837
Informations de publication
Date de publication:
15 09 2019
15 09 2019
Historique:
received:
23
08
2018
pubmed:
29
1
2019
medline:
17
6
2020
entrez:
29
1
2019
Statut:
ppublish
Résumé
Brief periods of physical inactivity can compromise muscle health. Increasing dietary protein intake is potentially beneficial but complicated by difficulties reconciling anabolic potential with a realistic food volume and energy intake. We sought to determine whether increasing dietary protein quality could reduce the negative effects of physical inactivity. Twenty healthy, older men and women completed 7 days of bed rest followed by 5 days of rehabilitation. Volunteers consumed a mixed macronutrient diet (MIXED: N = 10; 68 ± 2 years; 1,722 ± 29 kcal/day; 0.97 ± 0.01 g protein/kg/day) or an isoenergetic, whey-augmented, higher protein quality diet (WHEY: N = 10; 69 ± 1 years; 1,706 ± 23 kcal/day; 0.90 ± 0.01 g protein/kg/day). Outcomes included body composition, blood glucose, insulin, and a battery of physical function tests. During bed rest, both groups experienced a 20% reduction in knee extension peak torque (p < .05). The WHEY diet partially protected leg lean mass (-1,035 vs. -680 ± 138 g, MIXED vs. WHEY; p = .08) and contributed to a greater loss of body fat (-90 vs. -233 ± 152 g, MIXED vs. WHEY; p < .05). Following rehabilitation, knee extension peak torque in the WHEY group fully recovered (-10.0 vs. 2.2 ± 4.1 Nm, MIXED vs. WHEY; p = .05). Blood glucose, insulin, aerobic capacity, and Short Physical Performance Battery (SPPB) changes were similar in both dietary conditions (p > .05). Improving protein quality without increasing total energy intake has the potential to partially counter some of the negative effects of bed rest in older adults.
Sections du résumé
BACKGROUND
Brief periods of physical inactivity can compromise muscle health. Increasing dietary protein intake is potentially beneficial but complicated by difficulties reconciling anabolic potential with a realistic food volume and energy intake. We sought to determine whether increasing dietary protein quality could reduce the negative effects of physical inactivity.
METHODS
Twenty healthy, older men and women completed 7 days of bed rest followed by 5 days of rehabilitation. Volunteers consumed a mixed macronutrient diet (MIXED: N = 10; 68 ± 2 years; 1,722 ± 29 kcal/day; 0.97 ± 0.01 g protein/kg/day) or an isoenergetic, whey-augmented, higher protein quality diet (WHEY: N = 10; 69 ± 1 years; 1,706 ± 23 kcal/day; 0.90 ± 0.01 g protein/kg/day). Outcomes included body composition, blood glucose, insulin, and a battery of physical function tests.
RESULTS
During bed rest, both groups experienced a 20% reduction in knee extension peak torque (p < .05). The WHEY diet partially protected leg lean mass (-1,035 vs. -680 ± 138 g, MIXED vs. WHEY; p = .08) and contributed to a greater loss of body fat (-90 vs. -233 ± 152 g, MIXED vs. WHEY; p < .05). Following rehabilitation, knee extension peak torque in the WHEY group fully recovered (-10.0 vs. 2.2 ± 4.1 Nm, MIXED vs. WHEY; p = .05). Blood glucose, insulin, aerobic capacity, and Short Physical Performance Battery (SPPB) changes were similar in both dietary conditions (p > .05).
CONCLUSIONS
Improving protein quality without increasing total energy intake has the potential to partially counter some of the negative effects of bed rest in older adults.
Identifiants
pubmed: 30689727
pii: 5303369
doi: 10.1093/gerona/glz003
pmc: PMC6748768
doi:
Substances chimiques
Whey Proteins
0
Types de publication
Controlled Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1605-1611Subventions
Organisme : NIA NIH HHS
ID : P30 AG024832
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR012973
Pays : United States
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Diabetes Care. 2000 Mar;23(3):295-301
pubmed: 10868854
Am J Phys Med Rehabil. 2003 Aug;82(8):639-52
pubmed: 12872021
J Clin Endocrinol Metab. 2004 Sep;89(9):4351-8
pubmed: 15356032
Exp Gerontol. 2006 Feb;41(2):215-9
pubmed: 16310330
Curr Opin Clin Nutr Metab Care. 2009 Jan;12(1):86-90
pubmed: 19057193
Am J Clin Nutr. 2009 Sep;90(3):505-10
pubmed: 19640947
Clin Nutr. 2010 Apr;29(2):160-9
pubmed: 19828215
Curr Opin Clin Nutr Metab Care. 2010 Jan;13(1):34-9
pubmed: 19898232
J Am Geriatr Soc. 2011 Jan;59(1):91-5
pubmed: 21158744
J Am Med Dir Assoc. 2011 May;12(4):243-6
pubmed: 21527163
Clin Geriatr Med. 2011 Aug;27(3):423-47
pubmed: 21824556
Curr Opin Clin Nutr Metab Care. 2012 Jan;15(1):71-7
pubmed: 22037013
Clin Nutr. 2012 Aug;31(4):512-9
pubmed: 22357161
Br J Nutr. 2012 Aug;108 Suppl 2:S333-6
pubmed: 23107546
Clin Nutr. 2013 Oct;32(5):704-12
pubmed: 23514626
J Am Med Dir Assoc. 2013 Aug;14(8):542-59
pubmed: 23867520
Acta Physiol (Oxf). 2014 Mar;210(3):600-11
pubmed: 24168489
J Clin Densitom. 2013 Oct-Dec;16(4):520-36
pubmed: 24183641
J Nutr. 2015 Feb;145(2):372-9
pubmed: 25644361
Am J Clin Nutr. 2016 Feb;103(2):465-73
pubmed: 26718415
J Appl Physiol (1985). 2016 Apr 15;120(8):965-75
pubmed: 26796754
Am J Clin Nutr. 2016 Mar;103(3):830-40
pubmed: 26864356
J Nutr. 2016 May;146(5):929-32
pubmed: 27052532
Acta Physiol (Oxf). 2016 Sep;218(1):10-2
pubmed: 27124248
Physiol Meas. 2016 Sep 21;37(10):1872-1884
pubmed: 27654492
Appl Physiol Nutr Metab. 2017 Jun;42(6):563-570
pubmed: 28177712
Br J Nutr. 2017 Feb;117(4):490-499
pubmed: 28382889
Nutr Clin Pract. 2017 Apr;32(1_suppl):48S-57S
pubmed: 28388379
Br J Sports Med. 2018 Mar;52(6):376-384
pubmed: 28698222
Phys Ther. 2017 Nov 1;97(11):1044-1065
pubmed: 29077906
Nutr Clin Pract. 2018 Jun;33(3):325-332
pubmed: 29701916
J Dairy Sci. 2018 Aug;101(8):6691-6702
pubmed: 29885888
J Aging Phys Act. 2019 Apr 1;27(2):191-197
pubmed: 29989486
J Gerontol. 1994 Mar;49(2):M85-94
pubmed: 8126356
Diabetes Care. 1994 Feb;17(2):152-4
pubmed: 8137688
Crit Rev Food Sci Nutr. 1993;33(6):431-76
pubmed: 8216810