Differentiating Streptococcus pseudoporcinus from GBS: could this have implications in pregnancy?
Adult
Black or African American
Agglutination Tests
Anti-Bacterial Agents
/ pharmacology
Body Mass Index
Clindamycin
/ pharmacology
Cohort Studies
Drug Resistance, Bacterial
Female
Fetal Membranes, Premature Rupture
/ epidemiology
Humans
Infant, Newborn
Intensive Care Units, Neonatal
Patient Admission
Pregnancy
Pregnancy Complications, Infectious
/ microbiology
Premature Birth
/ epidemiology
Retrospective Studies
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Streptococcal Infections
/ epidemiology
Streptococcus
/ isolation & purification
Streptococcus agalactiae
/ isolation & purification
Tobacco Use
GBS
GBS colonization in pregnancy
Streptococcus agalactiae
Streptococcus pseudoporcinus
preterm birth
preterm premature rupture of membranes
Journal
American journal of obstetrics and gynecology
ISSN: 1097-6868
Titre abrégé: Am J Obstet Gynecol
Pays: United States
ID NLM: 0370476
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
09
11
2018
revised:
13
01
2019
accepted:
21
01
2019
pubmed:
29
1
2019
medline:
18
12
2019
entrez:
29
1
2019
Statut:
ppublish
Résumé
Streptococcus agalactiae (GBS) is a common pathogen known to cause neonatal and maternal infectious morbidity. Streptococcus pseudoporcinus (S pseudoporcinus) is a separate, recently identified β-hemolytic gram-positive coccus that can cause false-positive results on standard GBS agglutination testing assays. To determine the prevalence and clinical implications of Streptococcus pseudoporcinus colonization in pregnancy. This is a 2-year retrospective cohort study comparing pregnant women colonized with GBS to those colonized with S. pseudoporcinus. A proteomics method of identification, namely, matrix-assisted laser desorption ionization time-of-flight mass spectrometry, was used to distinguish between S. pseudoporcinus and GBS colonization. Antibiotic susceptibility testing was carried out on all specimens. Maternal and neonatal chart reviews were conducted to identify predictors of S. pseudoporcinus colonization and to compare maternal and neonatal outcomes. S. pseudoporcinus colonization occurred in 1.6% of all pregnancies. A total of 2.5% of all GBS-positive results by agglutination assay were false positive, instead reflecting S. pseudoporcinus colonization. Clindamycin resistance among S. pseudoporcinus isolates is uncommon. S. pseudoporcinus colonization in pregnancy is independently associated with African American race, tobacco use, and body mass index ≥35. Preterm premature rupture of membranes or spontaneous preterm birth was more common in patients colonized with S. pseudoporcinus. Although the prevalence of S. pseudoporcinus colonization is low, it primarily occurs in African American women and is associated with preterm premature rupture of membranes or spontaneous preterm birth when compared to individuals colonized with GBS.
Sections du résumé
BACKGROUND
Streptococcus agalactiae (GBS) is a common pathogen known to cause neonatal and maternal infectious morbidity. Streptococcus pseudoporcinus (S pseudoporcinus) is a separate, recently identified β-hemolytic gram-positive coccus that can cause false-positive results on standard GBS agglutination testing assays.
OBJECTIVE
To determine the prevalence and clinical implications of Streptococcus pseudoporcinus colonization in pregnancy.
MATERIALS AND METHODS
This is a 2-year retrospective cohort study comparing pregnant women colonized with GBS to those colonized with S. pseudoporcinus. A proteomics method of identification, namely, matrix-assisted laser desorption ionization time-of-flight mass spectrometry, was used to distinguish between S. pseudoporcinus and GBS colonization. Antibiotic susceptibility testing was carried out on all specimens. Maternal and neonatal chart reviews were conducted to identify predictors of S. pseudoporcinus colonization and to compare maternal and neonatal outcomes.
RESULTS
S. pseudoporcinus colonization occurred in 1.6% of all pregnancies. A total of 2.5% of all GBS-positive results by agglutination assay were false positive, instead reflecting S. pseudoporcinus colonization. Clindamycin resistance among S. pseudoporcinus isolates is uncommon. S. pseudoporcinus colonization in pregnancy is independently associated with African American race, tobacco use, and body mass index ≥35. Preterm premature rupture of membranes or spontaneous preterm birth was more common in patients colonized with S. pseudoporcinus.
CONCLUSION
Although the prevalence of S. pseudoporcinus colonization is low, it primarily occurs in African American women and is associated with preterm premature rupture of membranes or spontaneous preterm birth when compared to individuals colonized with GBS.
Identifiants
pubmed: 30690012
pii: S0002-9378(19)30249-2
doi: 10.1016/j.ajog.2019.01.219
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Clindamycin
3U02EL437C
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
490.e1-490.e7Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.