Maternal inflammation during pregnancy and offspring psychiatric symptoms in childhood: Timing and sex matter.
Adult
Behavioral Symptoms
/ etiology
Child
Cytokines
/ blood
Female
Humans
Inflammation
/ blood
Longitudinal Studies
Male
Pregnancy
Pregnancy Complications
/ blood
Pregnancy Trimester, First
/ blood
Pregnancy Trimester, Second
/ blood
Prenatal Exposure Delayed Effects
/ etiology
Sex Characteristics
Sex Factors
Anxiety
Children
Conduct problems
Depression
Maternal inflammation during pregnancy
Journal
Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
29
08
2018
revised:
21
11
2018
accepted:
07
01
2019
pubmed:
29
1
2019
medline:
18
6
2020
entrez:
29
1
2019
Statut:
ppublish
Résumé
Maternal infection during pregnancy has been associated with increased risk of offspring psychopathology, including depression. As most infections do not cross the placenta, maternal immune responses to infection have been considered as potentially contributing to this relationship. This study examined whether gestational timing of maternal inflammation during pregnancy is associated with offspring internalizing and/or externalizing symptoms during childhood and, further, whether fetal sex moderated this relationship. Participants were 737 pregnant women and their offspring who were continuously followed through late childhood. Archived first and second trimester sera were analyzed for markers of inflammation [interleukin 8 (IL-8), IL-6, IL-1 receptor antagonist (IL-1ra), and soluble tumor necrosis factor receptor-II (sTNF-RII)]. When offspring were aged 9-11, mothers completed a questionnaire assessing psychological symptoms. Multivariate regression analyses indicated that elevated IL-8 in the first trimester was associated with significantly higher levels of externalizing symptoms in offspring. Higher IL-1ra in the second trimester was associated with higher offspring internalizing symptoms. Further, second trimester IL-1ra was associated with increased internalizing symptoms in females only. These findings demonstrate that elevated maternal inflammation during pregnancy is associated with the emergence of separate psychological phenotypes and that timing of exposure and fetal sex matter for offspring outcomes. Given that internalizing and externalizing symptoms in childhood increase risk for a variety of mental disorders later in development, these findings potentially have major implications for early intervention and prevention work.
Identifiants
pubmed: 30690329
pii: S0022-3956(18)31033-1
doi: 10.1016/j.jpsychires.2019.01.009
pmc: PMC6644717
mid: NIHMS1519698
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
96-103Subventions
Organisme : NIMH NIH HHS
ID : R01 MH096478
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH101168
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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