Styk1 expression is a hallmark of murine NK cells and other NK1.1
Development
Innate lymphoid cells
Natural Killer cells
Receptor tyrosine kinase
Transcription
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
28
05
2018
revised:
29
11
2018
accepted:
24
01
2019
pubmed:
29
1
2019
medline:
27
5
2020
entrez:
29
1
2019
Statut:
ppublish
Résumé
To gain insight into the biology of NK cells, others and we previously identified the NK-cell signature, defined as the set of transcripts which expression is highly enriched in these cells compared to other immune subtypes. The transcript encoding the Serine/threonine/tyrosine kinase 1 (Styk1) is part of this signature. However, the role of Styk1 in the immune system is unknown. Here, we report the generation of a novel transgenic mouse model, in which Styk1 expression is invalidated and replaced by an EGFP reporter cassette. We demonstrated that Styk1 expression is a hallmark of NK cells and other NK1.1 expressing cells such as liver type 1 innate lymphoid cells (ILC1) and NK1.1
Identifiants
pubmed: 30690705
doi: 10.1002/eji.201847721
pmc: PMC8351758
mid: NIHMS1717961
doi:
Substances chimiques
RNA, Messenger
0
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
677-685Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIAID NIH HHS
ID : R00 AI085034
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI100874
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130043
Pays : United States
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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