The PERK Branch of the Unfolded Protein Response Promotes DLL4 Expression by Activating an Alternative Translation Mechanism.
DLL4 (delta like ligand 4)
IRES (internal ribosome entry site)
PERK (PKR-Like endoplasmic reticulum kinase)
UPR (unfolded protein response)
angiogenesis
endoplasmic reticulum stress
hypoxia
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
25 Jan 2019
25 Jan 2019
Historique:
received:
03
12
2018
revised:
15
01
2019
accepted:
22
01
2019
entrez:
30
1
2019
pubmed:
30
1
2019
medline:
30
1
2019
Statut:
epublish
Résumé
Delta-like 4 (DLL4) is a pivotal endothelium specific Notch ligand that has been shown to function as a regulating factor during physiological and pathological angiogenesis. DLL4 functions as a negative regulator of angiogenic branching and sprouting. Interestingly,
Identifiants
pubmed: 30691003
pii: cancers11020142
doi: 10.3390/cancers11020142
pmc: PMC6406545
pii:
doi:
Types de publication
Journal Article
Langues
eng
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