Profiling of Invasive Breast Carcinoma Circulating Tumour Cells-Are We Ready for the 'Liquid' Revolution?
circulating tumour cells
gene signatures
invasive breast cancer
predictive/prognostic multiparametric panels
single cells analysis
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
25 Jan 2019
25 Jan 2019
Historique:
received:
14
12
2018
revised:
21
01
2019
accepted:
22
01
2019
entrez:
30
1
2019
pubmed:
30
1
2019
medline:
30
1
2019
Statut:
epublish
Résumé
As dissemination through blood and lymph is the critical step of the metastatic cascade, circulating tumour cells (CTCs) have attracted wide attention as a potential surrogate marker to monitor progression into metastatic disease and response to therapy. In patients with invasive breast carcinoma (IBC), CTCs are being considered nowadays as a valid counterpart for the assessment of known prognostic and predictive factors. Molecular characterization of CTCs using protein detection, genomic and transcriptomic panels allows to depict IBC biology. Such molecular profiling of circulating cells with increased metastatic abilities appears to be essential, especially after tumour resection, as well as in advanced disseminated disease, when information crucial for identification of therapeutic targets becomes unobtainable from the primary site. If CTCs are truly representative of primary tumours and metastases, characterization of the molecular profile of this easily accessible 'biopsy' might be of prime importance for clinical practice in IBC patients. This review summarizes available data on feasibility and documented benefits of monitoring of essential IBC biological features in CTCs, with special reference to multifactorial proteomic, genomic, and transcriptomic panels of known prognostic or predictive value.
Identifiants
pubmed: 30691008
pii: cancers11020143
doi: 10.3390/cancers11020143
pmc: PMC6406427
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Narodowe Centrum Nauki
ID : 2016/21/D/NZ3/02629 and 2018/29/N/NZ4/02384
Organisme : Medical University of Lodz
ID : UMO 502-03/1-034-03/502-14-384-18
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. The funders had no role in preparation of the manuscript.
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