Asthma and Corticosteroid Responses in Childhood and Adult Asthma.

Administration, Inhalation Adrenal Cortex Hormones / pharmacology Adult Anti-Asthmatic Agents / pharmacology Asthma / drug therapy Child Humans Treatment Outcome
Adult asthma Childhood asthma Corticosteroid resistance Corticosteroid response Inhaled corticosteroids

Journal

Clinics in chest medicine
ISSN: 1557-8216
Titre abrégé: Clin Chest Med
Pays: United States
ID NLM: 7907612

Informations de publication

Date de publication:
03 2019
Historique:
entrez: 30 1 2019
pubmed: 30 1 2019
medline: 29 1 2020
Statut: ppublish

Résumé

Corticosteroids are the most effective treatment for asthma; inhaled corticosteroids (ICSs) are the first-line treatment for children and adults with persistent symptoms. ICSs are associated with significant improvements in lung function. The anti-inflammatory effects of corticosteroids are mediated by both genomic and nongenomic factors. Variation in the response to corticosteroids has been observed. Patient characteristics, biomarkers, and genetic features may be used to predict response to ICSs. The existence of multiple mechanisms underlying glucocorticoid insensitivity raises the possibility that this might indeed reflect different diseases with a common phenotype.

Identifiants

DOI: 10.1016/j.ccm.2018.10.010 PMID: 30691710 PMC: PMC6355159
pubmed: 30691710
pii: S0272-5231(18)30121-7
doi: 10.1016/j.ccm.2018.10.010
pmc: PMC6355159
mid: NIHMS1509744
pii:
doi:

Substances chimiques

Adrenal Cortex Hormones 0
Anti-Asthmatic Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

163-177

Subventions

Organisme : NHLBI NIH HHS
ID : UG1 HL139124
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI106945
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES030100
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001102
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL109172
Pays : United States
Organisme : NIAID NIH HHS
ID : K24 AI106822
Pays : United States

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

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Auteurs

Amira Ali Ramadan (AA)

Division of Allergy and Immunology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Beth Israel Deaconess Center, Cardiovascular institute, 330 Brookline Avenue, Boston, MA 02215, USA.

Jonathan M Gaffin (JM)

Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA.

Elliot Israel (E)

Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Brigham and Women's Hospital, 15 Francis Street, Boston, MA 02115, USA.

Wanda Phipatanakul (W)

Division of Allergy and Immunology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address: Wanda.Phipatanakul@childrens.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par inhalation › Asthma and Corticosteroid Responses in...
questionsmedicales.fr › Hormones corticosurrénaliennes › Asthma and Corticosteroid Responses in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Asthma and Corticosteroid Responses in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents de l'appareil respiratoire › Antiasthmatiques › Asthma and Corticosteroid Responses in...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Asthma and Corticosteroid Responses in...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Asthma and Corticosteroid Responses in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Asthma and Corticosteroid Responses in...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Asthma and Corticosteroid Responses in...