The Ciliopathy Gene
Adaptor Proteins, Signal Transducing
/ genetics
Animals
Eye
/ embryology
Hedgehog Proteins
/ metabolism
Hypothalamus
/ embryology
Mice, Inbred C57BL
Mice, Knockout
Nerve Tissue Proteins
/ metabolism
Prosencephalon
/ embryology
Signal Transduction
Thalamus
/ embryology
Zinc Finger Protein Gli3
/ metabolism
Hedgehog/Gli signaling
Rpgrip1l
ciliopathy
forebrain patterning
primary cilia
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
27 03 2019
27 03 2019
Historique:
received:
27
08
2018
revised:
22
12
2018
accepted:
15
01
2019
pubmed:
30
1
2019
medline:
19
3
2020
entrez:
30
1
2019
Statut:
ppublish
Résumé
Primary cilia are essential for CNS development. In the mouse, they play a critical role in patterning the spinal cord and telencephalon via the regulation of Hedgehog/Gli signaling. However, despite the frequent disruption of this signaling pathway in human forebrain malformations, the role of primary cilia in forebrain morphogenesis has been little investigated outside the telencephalon. Here we studied development of the diencephalon, hypothalamus and eyes in mutant mice in which the
Identifiants
pubmed: 30692221
pii: JNEUROSCI.2199-18.2019
doi: 10.1523/JNEUROSCI.2199-18.2019
pmc: PMC6435827
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Ftm protein, mouse
0
Gli3 protein, mouse
0
Hedgehog Proteins
0
Nerve Tissue Proteins
0
Shh protein, mouse
0
Zinc Finger Protein Gli3
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2398-2415Informations de copyright
Copyright © 2019 Andreu-Cervera et al.
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