Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors.
Notch signaling
Presenilin enhancer 2
neural stem cell
neurogenesis
γ-secretase
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
20 03 2019
20 03 2019
Historique:
received:
30
09
2018
revised:
08
01
2019
accepted:
11
01
2019
pubmed:
30
1
2019
medline:
17
3
2020
entrez:
30
1
2019
Statut:
ppublish
Résumé
The transition of apical progenitors (APs) to basal progenitors (BPs) is an important neurogenic process during cortical expansion. Presenilin enhancer 2 (Pen-2, also named as Psenen) is a key subunit of γ-secretase and has been implicated in neurodevelopmental disease. However, it remains unknown how Pen-2 may regulate the maintenance of APs. To address this question, we generated a conditional KO (cKO) mouse in which Pen-2 is specifically inactivated in neural progenitor cells in the telencephalon. Both male and female embryos were used. We show that
Identifiants
pubmed: 30692224
pii: JNEUROSCI.2523-18.2019
doi: 10.1523/JNEUROSCI.2523-18.2019
pmc: PMC6433762
doi:
Substances chimiques
Notch1 protein, mouse
0
Receptor, Notch1
0
Amyloid Precursor Protein Secretases
EC 3.4.-
presenilin enhancer 2, mouse
EC 3.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2195-2207Informations de copyright
Copyright © 2019 the authors 0270-6474/19/392195-13$15.00/0.
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