Prevention of schizophrenia deficits via non-invasive adolescent frontal cortex stimulation in rats.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
02
10
2017
accepted:
20
12
2018
revised:
28
11
2018
pubmed:
30
1
2019
medline:
18
2
2021
entrez:
30
1
2019
Statut:
ppublish
Résumé
Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-invasive transcranial direct current stimulation (tDCS) during adolescence, prior to schizophrenia-relevant behavioral manifestation, prevents the development of positive symptoms and related neurobiological alterations in the maternal immune stimulation (MIS) model of schizophrenia.
Identifiants
pubmed: 30692610
doi: 10.1038/s41380-019-0356-x
pii: 10.1038/s41380-019-0356-x
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
896-905Commentaires et corrections
Type : CommentIn
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