Influence of buffy coat-derived putative endothelial progenitor cells on tumor growth and neovascularization in oral squamous cell carcinoma xenografts.


Journal

Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 04 07 2018
accepted: 11 01 2019
pubmed: 30 1 2019
medline: 18 12 2019
entrez: 30 1 2019
Statut: ppublish

Résumé

The aim of this murine in vivo study was to investigate whether buffy coat-derived putative endothelial progenitor cells (BC A murine xenograft model using the PCI-13 oral cancer cell line was deployed of which n = 24 animals received 2 × 10 In the experimental group, systemic application of BC Immunohistochemical investigations support the notion that BC Endothelial progenitor cells (EPCs) could serve as a target structure for the treatment of OSCC and possibly other solid tumors.

Identifiants

pubmed: 30693401
doi: 10.1007/s00784-019-02806-2
pii: 10.1007/s00784-019-02806-2
doi:

Types de publication

Journal Article

Langues

eng

Pagination

3767-3775

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Auteurs

Marius Otto (M)

Interdisciplinary Head & Neck Oncology Laboratory, Department for Oral and Maxillofacial Surgery, University Hospital Giessen and Marburg, Campus Marburg, Baldingerstrasse, D-35033, Marburg, Germany.

Sebastian Blatt (S)

Clinic for Oral and Maxillofacial Surgery, University Medical Center Mainz, Mainz, Germany.

Andreas Pabst (A)

Clinic for Oral and Maxillofacial Surgery, Federal Armed Forces Hospital Koblenz, Koblenz, Germany.

Robert Mandic (R)

Interdisciplinary Head & Neck Oncology Laboratory, Department of Otolaryngology, Head & Neck Surgery, University Hospital Marburg, Marburg, Germany.

Johanna Schwarz (J)

Department of Mathematics and Computer Science, Research Group for Bioinformatics, Philipps-Universität Marburg, Marburg, Germany.

Andreas Neff (A)

Interdisciplinary Head & Neck Oncology Laboratory, Department for Oral and Maxillofacial Surgery, University Hospital Giessen and Marburg, Campus Marburg, Baldingerstrasse, D-35033, Marburg, Germany.

Thomas Ziebart (T)

Interdisciplinary Head & Neck Oncology Laboratory, Department for Oral and Maxillofacial Surgery, University Hospital Giessen and Marburg, Campus Marburg, Baldingerstrasse, D-35033, Marburg, Germany. ziebart@med.uni-marburg.de.

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