Reversible Covalent Stabilization of Stacking Contacts in DNA Assemblies.
3-cyanovinylcarbazole
DNA nanotechnology
DNA origami
covalent stabilization
photo-crosslinking
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
25 02 2019
25 02 2019
Historique:
received:
30
10
2018
pubmed:
30
1
2019
medline:
30
1
2019
entrez:
30
1
2019
Statut:
ppublish
Résumé
Stacking bonds formed between two blunt-ended DNA double helices can be used to reversibly stabilize higher-order complexes that are assembled from rigid DNA components. Typically, at low cation concentrations, stacking bonds break and thus higher-order complexes disassemble. Herein, we present a site-specific photochemical mechanism for the reversible covalent stabilization of stacking bonds in DNA assemblies. To this end, we modified one blunt end with the 3-cyanovinylcarbazole (
Identifiants
pubmed: 30694591
doi: 10.1002/anie.201812463
pmc: PMC6984961
mid: EMS85570
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2680-2684Subventions
Organisme : DFG
ID : Excellence Cluster CIPSM
Pays : International
Organisme : European Research Council
ID : 256270
Pays : International
Organisme : H2020 European Research Council
ID : 724261
Pays : International
Organisme : DFG
ID : SFB863 TPA9
Pays : International
Organisme : DFG
ID : Gottfried-Wilhelm-Leibniz
Pays : International
Organisme : Technische Universität München
ID : Institute for Advanced Study
Pays : International
Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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