TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals.
Adaptor Proteins, Signal Transducing
/ genetics
Animals
Arabidopsis
/ genetics
Arabidopsis Proteins
/ genetics
COP9 Signalosome Complex
/ genetics
Cell Cycle Checkpoints
/ genetics
Cell Division
/ genetics
Cell Proliferation
/ genetics
Cullin Proteins
/ genetics
Drosophila
/ genetics
Drosophila Proteins
/ genetics
Microtubule-Associated Proteins
/ genetics
Nicotiana
/ genetics
Ubiquitin
Journal
PLoS genetics
ISSN: 1553-7404
Titre abrégé: PLoS Genet
Pays: United States
ID NLM: 101239074
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
16
03
2018
accepted:
15
12
2018
revised:
08
02
2019
pubmed:
30
1
2019
medline:
12
3
2019
entrez:
30
1
2019
Statut:
epublish
Résumé
Translationally Controlled Tumor Protein (TCTP) controls growth by regulating the G1/S transition during cell cycle progression. Our genetic interaction studies show that TCTP fulfills this role by interacting with CSN4, a subunit of the COP9 Signalosome complex, known to influence CULLIN-RING ubiquitin ligases activity by controlling CULLIN (CUL) neddylation status. In agreement with these data, downregulation of CSN4 in Arabidopsis and in tobacco cells leads to delayed G1/S transition comparable to that observed when TCTP is downregulated. Loss-of-function of AtTCTP leads to increased fraction of deneddylated CUL1, suggesting that AtTCTP interferes negatively with COP9 function. Similar defects in cell proliferation and CUL1 neddylation status were observed in Drosophila knockdown for dCSN4 or dTCTP, respectively, demonstrating a conserved mechanism between plants and animals. Together, our data show that CSN4 is the missing factor linking TCTP to the control of cell cycle progression and cell proliferation during organ development and open perspectives towards understanding TCTP's role in organ development and disorders associated with TCTP miss-expression.
Identifiants
pubmed: 30695029
doi: 10.1371/journal.pgen.1007899
pii: PGENETICS-D-18-00533
pmc: PMC6368322
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Arabidopsis Proteins
0
CSN4 protein, Drosophila
0
Cullin 1
0
Cullin Proteins
0
Drosophila Proteins
0
Microtubule-Associated Proteins
0
TCTP protein, Arabidopsis
0
Ubiquitin
0
COP9 Signalosome Complex
EC 3.4.19.12
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1007899Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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