Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models.
Animals
Astrocytes
/ pathology
Axons
/ metabolism
Biomarkers
/ metabolism
Carbazoles
/ metabolism
Cuprizone
Demyelinating Diseases
/ diagnostic imaging
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental
/ diagnostic imaging
Female
Inflammation
/ pathology
Ligands
Mice, Inbred C57BL
Mitochondria
/ metabolism
Monocytes
/ metabolism
Multiple Sclerosis
/ diagnostic imaging
Neuroglia
/ metabolism
RNA, Messenger
/ genetics
Receptors, GABA
/ genetics
Kewords: multiple sclerosis
PET
TSPO
cuprizone
neurodegeneration
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
28 01 2019
28 01 2019
Historique:
received:
20
11
2018
revised:
16
01
2019
accepted:
23
01
2019
entrez:
31
1
2019
pubmed:
31
1
2019
medline:
31
1
2019
Statut:
epublish
Résumé
Positron emission tomography (PET) ligands targeting the translocator protein (TSPO) represent promising tools to visualize neuroinflammation in multiple sclerosis (MS). Although it is known that TSPO is expressed in the outer mitochondria membrane, its cellular localization in the central nervous system under physiological and pathological conditions is not entirely clear. The purpose of this study was to assess the feasibility of utilizing PET imaging with the TSPO tracer, [18F]-GE180, to detect histopathological changes during experimental demyelination, and to determine which cell types express TSPO. C57BL/6 mice were fed with cuprizone for up to 5 weeks to induce demyelination. Groups of mice were investigated by [18F]-GE180 PET imaging at week 5. Recruitment of peripheral immune cells was triggered by combining cuprizone intoxication with MOG
Identifiants
pubmed: 30696113
pii: cells8020094
doi: 10.3390/cells8020094
pmc: PMC6406715
pii:
doi:
Substances chimiques
Biomarkers
0
Bzrp protein, mouse
0
Carbazoles
0
GE-180
0
Ligands
0
RNA, Messenger
0
Receptors, GABA
0
Cuprizone
5N16U7E0AO
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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