Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation.
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
12 02 2019
12 02 2019
Historique:
received:
30
09
2018
accepted:
11
12
2018
entrez:
31
1
2019
pubmed:
31
1
2019
medline:
20
3
2020
Statut:
ppublish
Résumé
Antibody ligation of the murine neutrophil surface protein Ly6G disrupts neutrophil migration in some contexts but not others. We tested whether this variability reflected divergent dependence of neutrophil migration on β2 integrins, adhesion molecules that interact with Ly6G at the neutrophil surface. In integrin-dependent murine arthritis, Ly6G ligation attenuated joint inflammation, even though mice lacking Ly6G altogether developed arthritis normally. By contrast, Ly6G ligation had no impact on integrin-independent neutrophil migration into inflamed lung. In peritoneum, the role of β2 integrins varied with stimulus, proving dispensable for neutrophil entry in
Identifiants
pubmed: 30696624
pii: bloodadvances.2018026732
doi: 10.1182/bloodadvances.2018026732
pmc: PMC6373735
doi:
Substances chimiques
Antigens, Ly
0
CD18 Antigens
0
Ly6G antigen, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
256-267Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR070253
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR065538
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM124911
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007512
Pays : United States
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2019 by The American Society of Hematology.
Références
J Biol Chem. 2007 Aug 10;282(32):23603-12
pubmed: 17580308
J Exp Med. 1997 Oct 20;186(8):1357-64
pubmed: 9334375
Science. 1992 Jul 24;257(5069):548-51
pubmed: 1636093
Pediatr Pathol. 1992 Jan-Feb;12(1):119-30
pubmed: 1348581
J Clin Invest. 1971 May;50(5):1108-15
pubmed: 5552408
J Leukoc Biol. 1997 Feb;61(2):167-72
pubmed: 9021922
J Immunol. 1990 Mar 15;144(6):2327-33
pubmed: 1968927
Immunity. 2014 Nov 20;41(5):694-707
pubmed: 25517612
Blood. 2017 Nov 9;130(19):2092-2100
pubmed: 28807980
Cell. 1987 Jul 17;50(2):193-202
pubmed: 3594570
Eur J Immunol. 2009 Dec;39(12):3538-51
pubmed: 19830733
J Exp Med. 1998 Jul 6;188(1):119-31
pubmed: 9653089
Am J Physiol Lung Cell Mol Physiol. 2003 Oct;285(4):L879-88
pubmed: 12818890
J Immunol. 2005 Mar 15;174(6):3668-75
pubmed: 15749905
J Leukoc Biol. 2017 Jan;101(1):321-328
pubmed: 27531929
Transfus Med. 1998 Jun;8(2):119-23
pubmed: 9675788
Nat Rev Immunol. 2013 Mar;13(3):159-75
pubmed: 23435331
Nat Methods. 2015 May;12(5):445-52
pubmed: 25775045
J Leukoc Biol. 2009 Jan;85(1):55-63
pubmed: 18927400
J Leukoc Biol. 2008 Jan;83(1):64-70
pubmed: 17884993
J Biol Chem. 2011 Mar 4;286(9):7070-81
pubmed: 21193407
Blood. 2012 May 3;119(18):4275-82
pubmed: 22431571
J Immunol. 2001 Aug 1;167(3):1601-8
pubmed: 11466382
Nature. 2013 Jun 20;498(7454):371-5
pubmed: 23708969
Blood. 2012 Aug 16;120(7):1489-98
pubmed: 22661700
PLoS Genet. 2016 May 26;12(5):e1006067
pubmed: 27227454
Trends Immunol. 2005 Jul;26(7):388-95
pubmed: 15922663
J Leukoc Biol. 2013 Oct;94(4):585-94
pubmed: 23543767
J Immunol. 1996 Dec 1;157(11):5016-21
pubmed: 8943409
J Immunol. 1999 Jul 15;163(2):995-9
pubmed: 10395697
Immunity. 1996 Dec;5(6):653-66
pubmed: 8986723
Am J Respir Cell Mol Biol. 2017 May;56(5):620-627
pubmed: 28157452
Nat Med. 2012 Sep;18(9):1386-93
pubmed: 22922410
J Leukoc Biol. 1998 Sep;64(3):291-7
pubmed: 9738654
J Exp Med. 2017 Jul 3;214(7):2089-2101
pubmed: 28559244
Blood. 2013 Jan 3;121(1):241-2
pubmed: 23287627
Protein Cell. 2015 Feb;6(2):117-26
pubmed: 25359465
Immunity. 2002 Apr;16(4):547-58
pubmed: 11970878
Am J Respir Cell Mol Biol. 1994 Apr;10(4):391-8
pubmed: 7510985
Science. 2010 Oct 15;330(6002):362-6
pubmed: 20947763
J Immunol. 1993 Sep 1;151(5):2399-408
pubmed: 8360469
Blood. 2003 Feb 1;101(3):921-8
pubmed: 12393622
Blood. 2011 Jan 20;117(3):942-52
pubmed: 21030556
J Exp Med. 2006 Nov 27;203(12):2569-75
pubmed: 17116736
Blood. 2001 Mar 15;97(6):1578-83
pubmed: 11238094
Transfusion. 1996 Feb;36(2):168-74
pubmed: 8614969
Curr Opin Hematol. 2007 Nov;14(6):688-93
pubmed: 17898576
J Leukoc Biol. 2017 Sep;102(3):677-683
pubmed: 28292945
PLoS Pathog. 2014 Oct 09;10(10):e1004379
pubmed: 25299673
J Immunol. 1999 Nov 1;163(9):5029-38
pubmed: 10528208