The orphan nuclear receptor Nor1/Nr4a3 is a negative regulator of β-cell mass.
Animals
Apoptosis
Cytokines
DNA-Binding Proteins
/ biosynthesis
Diabetes Mellitus, Type 2
/ genetics
Humans
Insulin-Secreting Cells
/ metabolism
Mice
Mice, Knockout
Nerve Tissue Proteins
/ biosynthesis
Nuclear Receptor Subfamily 4, Group A, Member 1
/ genetics
Receptors, Steroid
/ biosynthesis
Receptors, Thyroid Hormone
/ biosynthesis
Up-Regulation
Nr4a
apoptosis
cytokine
diabetes
insulin
nuclear receptor
pancreas
β-cell
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
29 03 2019
29 03 2019
Historique:
received:
30
07
2018
revised:
15
01
2019
pubmed:
31
1
2019
medline:
17
10
2019
entrez:
31
1
2019
Statut:
ppublish
Résumé
The Nr4a subfamily of nuclear receptor comprises three members in mammalian cells: Nur77/Nr4a1, Nurr1/Nr4a2, and Nor1/Nr4a3. Nr4a proteins play key roles in the regulation of glucose homeostasis in peripheral metabolic tissues. However, their biological functions in β-cells remain relatively uncharacterized. Here we sought to investigate the potential role of Nor1 in the regulation of β-cell mass and, in particular, β-cell survival/apoptosis. We used histological analysis to examine the consequences of genetic deletion of either
Identifiants
pubmed: 30696767
pii: S0021-9258(20)35542-3
doi: 10.1074/jbc.RA118.005135
pmc: PMC6442030
doi:
Substances chimiques
Cytokines
0
DNA-Binding Proteins
0
NR4A1 protein, human
0
NR4A3 protein, human
0
Nerve Tissue Proteins
0
Nr4a1 protein, mouse
0
Nr4a3 protein, mouse
0
Nuclear Receptor Subfamily 4, Group A, Member 1
0
Receptors, Steroid
0
Receptors, Thyroid Hormone
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4889-4897Informations de copyright
© 2019 Close et al.
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