Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice.
Animals
Disease Models, Animal
Ganglia, Spinal
/ metabolism
Hyperalgesia
/ metabolism
Immunity, Innate
Lectins, C-Type
/ metabolism
Macrophages
/ metabolism
Male
Membrane Proteins
/ metabolism
Mice
Mice, Inbred C57BL
Neuralgia
/ metabolism
Peripheral Nerve Injuries
/ metabolism
Receptors, Pattern Recognition
/ metabolism
Spinal Cord Dorsal Horn
/ metabolism
Spinal Nerves
/ pathology
Toll-Like Receptors
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 01 2019
29 01 2019
Historique:
received:
18
07
2018
accepted:
05
12
2018
entrez:
31
1
2019
pubmed:
31
1
2019
medline:
29
8
2020
Statut:
epublish
Résumé
Increasing evidence indicates that pattern recognition receptors (PRRs) are involved in neuropathic pain after peripheral nerve injury (PNI). While a significant number of studies support an association between neuropathic pain and the innate immune response mediated through Toll-like receptors, a family of PRRs, the roles of other types of PRRs are largely unknown. In this study, we have focused on the macrophage-inducible C-type lectin (Mincle), a PRR allocated to the C-type lectin receptor family. Here, we show that Mincle is involved in neuropathic pain after PNI. Mincle-deficient mice showed impaired PNI-induced mechanical allodynia. After PNI, expression of Mincle mRNA was rapidly increased in the injured spinal nerve. Most Mincle-expressing cells were identified as infiltrating leucocytes, although the migration of leucocytes was also observed in Mincle-deficient mice. Furthermore, Mincle-deficiency affected the induction of genes, which are reported to contribute to neuropathic pain after PNI in the dorsal root ganglia and spinal dorsal horn. These results suggest that Mincle is involved in triggering sequential processes that lead to the pathogenesis of neuropathic pain.
Identifiants
pubmed: 30696945
doi: 10.1038/s41598-018-37318-8
pii: 10.1038/s41598-018-37318-8
pmc: PMC6351622
doi:
Substances chimiques
Clecsf8 protein, mouse
0
Lectins, C-Type
0
Membrane Proteins
0
Receptors, Pattern Recognition
0
Toll-Like Receptors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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