Carotid artery calcification score and its association with cognitive impairment.
Aged
Calcinosis
/ complications
Carotid Stenosis
/ complications
Cognitive Dysfunction
/ etiology
Computed Tomography Angiography
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multidetector Computed Tomography
Plaque, Atherosclerotic
/ diagnostic imaging
Predictive Value of Tests
Retrospective Studies
Risk Factors
Severity of Illness Index
Ultrasonography, Doppler, Color
calcification score
carotid artery stenosis
cognitive impairment
plaque burden
Journal
Clinical interventions in aging
ISSN: 1178-1998
Titre abrégé: Clin Interv Aging
Pays: New Zealand
ID NLM: 101273480
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
31
1
2019
pubmed:
31
1
2019
medline:
14
3
2019
Statut:
epublish
Résumé
To retrospectively investigate the possible association between carotid artery calcification score (CS) and cognitive impairment in carotid artery stenosis (CAS) patients. Carotid artery was measured in 102 patients with cervical carotid arteries using Color Doppler ultrasound, multi-detector row spiral CT angiography and MRI scanning. Correlation analysis between CSs obtained by MD CT and cognitive scores was performed, and the correlation between CSs and vascular stenosis degree and MRI-measured plaque histological (lipid-rich necrotic nucleus [LRNC], intraplaque hemorrhage and fibrous cap surface rupture) and morphological parameters (lumen area [LA], wall area [WA], total area of blood vessels [TVA], plaque burden [PB]) was analyzed. Follow-up review analysis was conducted on 38 postoperative patients. Significant negative correlation was discovered between CS value and cognitive scores in CAS patients ( Carotid artery CSs have significant correlation with cognitive scores, which could be used as risk factor for early screening of cognitive impairment in CAS patients. The possible mechanism may be related to the calcification impact on the plaque burden.
Identifiants
pubmed: 30697041
doi: 10.2147/CIA.S192586
pii: cia-14-167
pmc: PMC6342141
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
167-177Déclaration de conflit d'intérêts
Disclosure The authors report no conflicts of interest in this work.
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