Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis.
efficacy
functional dyspepsia
meta-analysis
placebo
serotonin receptor
Journal
Archives of medical science : AMS
ISSN: 1734-1922
Titre abrégé: Arch Med Sci
Pays: Poland
ID NLM: 101258257
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
23
08
2016
accepted:
01
01
2017
entrez:
31
1
2019
pubmed:
31
1
2019
medline:
31
1
2019
Statut:
ppublish
Résumé
Functional dyspepsia (FD) is typically treated with serotonin receptor (5-HT) agonists such as cisapride, mosapride, tegaserod and tandospirone citrate. However, there are conflicting efficacy data, possibly due to significant heterogeneity between studies. In this meta-analysis, we analyzed the efficacy and safety data from studies evaluating the efficacy of serotonin receptor agonists in patients with FD. Relevant studies were selected from the Medline, Cochrane, EMBASE, and Google Scholar databases. The meta-analysis included 10 RCTs which evaluated the efficacy of serotonin receptor agonists in patients with FD (final total of 892 patients in the serotonin receptor agonist group, and 640 participants in the placebo group). The primary outcomes were the response rates and abdominal symptoms score. The Cochrane Collaboration's tool was used to assess risk. Sensitivity analysis was carried out using the leave-one-out approach. Patients treated with serotonin receptor agonists had a significantly higher response rate compared to placebo-treated patients (pooled OR = 2.99; 95% CI: 1.15-7.77; Serotonin receptor agonists had a significantly higher efficacy compared to placebo in the treatment of FD.
Identifiants
pubmed: 30697251
doi: 10.5114/aoms.2017.69234
pii: 30376
pmc: PMC6348349
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
23-32Références
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