Oxidative stress markers in patients with hereditary angioedema.
C1-inhibitor
bradykinin
hereditary angioedema
kinin
oxidative stress
Journal
Archives of medical science : AMS
ISSN: 1734-1922
Titre abrégé: Arch Med Sci
Pays: Poland
ID NLM: 101258257
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
02
10
2016
accepted:
18
01
2017
entrez:
31
1
2019
pubmed:
31
1
2019
medline:
31
1
2019
Statut:
ppublish
Résumé
Hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) or with normal C1-INH is characterized by recurrent swellings due to uncontrolled production of vasoactive mediators, among which bradykinin (BK) is crucial. Through the binding and activation of the two human BK-receptors, kinins may have dual beneficial and deleterious effects in vascular and inflammation physiopathology by inducing oxidative stress. We aimed to assess the serum concentrations of advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) in patients affected by HAE. Blood samples were collected to measure the serum concentrations of AGEs and AOPPs by spectrofluorimetric and spectrophotometric methods in patients affected by C1-INH-HAE and FXII-HAE during the remission state. We showed that the circulating levels of AOPPs observed on control group (0.94 (0.36) nmol/mg) were significantly lower than those observed on the C1-INH-HAE group (1.68 (0.47) nmol/mg; Our observations show additional underlying events involved in HAE and are of central importance for further investigations of differences in bradykinin receptors signaling among the two disease subgroups.
Identifiants
pubmed: 30697258
doi: 10.5114/aoms.2017.66160
pii: 29531
pmc: PMC6348350
doi:
Types de publication
Journal Article
Langues
eng
Pagination
92-98Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Circulation. 2001 Jun 26;103(25):3099-104
pubmed: 11425775
J Allergy Clin Immunol. 2002 Feb;109(2):195-209
pubmed: 11842287
J Allergy Clin Immunol. 2002 Sep;110(3):349-56
pubmed: 12209079
Int Immunopharmacol. 2003 Mar;3(3):311-7
pubmed: 12639808
G Ital Med Lav Ergon. 2004 Oct-Dec;26(4):298-301
pubmed: 15584436
Pharmacol Rev. 2005 Mar;57(1):27-77
pubmed: 15734727
Mutat Res. 2005 Nov 11;579(1-2):37-46
pubmed: 16084533
Biochem Biophys Res Commun. 2006 May 19;343(4):1286-9
pubmed: 16638441
Hypertension. 2007 Mar;49(3):490-7
pubmed: 17224475
J Allergy Clin Immunol. 2008 Apr;121(4):969-75.e2
pubmed: 18395553
Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):289-95
pubmed: 19221203
J Allergy Clin Immunol. 2009 Dec;124(6):1303-10.e4
pubmed: 19796797
J Appl Physiol (1985). 2010 Mar;108(3):754-9
pubmed: 19926826
Neuropeptides. 2010 Apr;44(2):145-54
pubmed: 20045558
Pol Merkur Lekarski. 2010 Feb;28(164):166-9
pubmed: 20369749
Allergy. 2011 Jan;66(1):76-84
pubmed: 20804470
PLoS One. 2010 Sep 07;5(9):e12622
pubmed: 20830306
Peptides. 2011 Jul;32(7):1447-56
pubmed: 21600945
PLoS One. 2011;6(5):e20036
pubmed: 21625439
J Clin Immunol. 2012 Feb;32(1):61-9
pubmed: 22009003
Curr Opin Nephrol Hypertens. 2012 Jan;21(1):92-6
pubmed: 22048723
Int J Hyg Environ Health. 2012 Apr;215(3):389-92
pubmed: 22153878
Int Immunopharmacol. 2012 Jan;12(1):212-6
pubmed: 22172644
Cancer Invest. 2012 Jan;30(1):20-6
pubmed: 22236186
Clin Exp Immunol. 2012 Mar;167(3):472-8
pubmed: 22288590
Int J Immunopathol Pharmacol. 2012 Jan-Mar;25(1):269-73
pubmed: 22507340
Inflamm Res. 2012 Oct;61(10):1063-7
pubmed: 22674324
Clin Biochem. 2012 Nov;45(16-17):1439-43
pubmed: 22850610
Clin Immunol. 2013 May;147(2):129-32
pubmed: 23583915
J Investig Allergol Clin Immunol. 2013;23(2):101-6
pubmed: 23654076
J Allergy Clin Immunol. 2013 Oct;132(4):986-9.e1-5
pubmed: 23849223
Clin Sci (Lond). 2014 Mar;126(6):441-9
pubmed: 24117346
Adv Immunol. 2014;121:41-89
pubmed: 24388213
Ann Hum Genet. 2014 Mar;78(2):73-82
pubmed: 24456027
Exp Neurol. 2014 Sep;259:16-27
pubmed: 24560819
Curr Vasc Pharmacol. 2014 Mar;12(2):223-48
pubmed: 24568157
Int Immunopharmacol. 2014 May;20(1):264-8
pubmed: 24667369
Allergy. 2014 May;69(5):602-16
pubmed: 24673465
Allergy. 2014 Dec;69(12):1659-65
pubmed: 25134986
J Allergy Clin Immunol. 2015 Apr;135(4):1031-43.e6
pubmed: 25240785
Inflammation. 2015;38(3):1201-6
pubmed: 25502444
Allergy Asthma Proc. 2015 Jan-Feb;36(1):9-13
pubmed: 25562550
Allergy. 2015 Apr;70(4):436-42
pubmed: 25630934
Allergy. 2015 May;70(5):506-13
pubmed: 25640891
Curr Drug Targets. 2015;16(8):895-903
pubmed: 25738298
Clin Immunol. 2015 Apr;157(2):239-48
pubmed: 25744496
Allergy. 2015 Aug;70(8):1004-12
pubmed: 25952149
Clin Immunol. 2015 Nov;161(1):59-63
pubmed: 26168705
J Clin Invest. 2015 Aug 3;125(8):3132-46
pubmed: 26193639
J Clin Immunol. 2016 Jan;36(1):95-102
pubmed: 26707788
J Clin Immunol. 2016 Feb;36(2):160-70
pubmed: 26873707
J Allergy Clin Immunol. 2016 Nov;138(5):1414-1423.e9
pubmed: 27130860
Lancet. 1998 Jun 6;351(9117):1693-7
pubmed: 9734886