Temporal whole field sawtooth flicker without a spatial component elicits a myopic shift following optical defocus irrespective of waveform direction in chicks.
Chick
Flicker
Myopia
Refractive compensation
Refractive error
Sawtooth
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2019
2019
Historique:
received:
12
03
2018
accepted:
11
12
2018
entrez:
31
1
2019
pubmed:
31
1
2019
medline:
31
1
2019
Statut:
epublish
Résumé
Myopia (short-sightedness) is the commonest visual disorder and greatest risk factor for sight threatening secondary pathologies. Myopia and hyperopia can be induced in animal models by rearing with optical lens defocus of opposite sign. The degree of refractive compensation to lens-induced defocus in chicks has been shown to be modified by directionally drifting sawtooth spatio-temporal luminance diamond plaids, with Fast-ON sawtooth spatio-temporal luminance profiles inhibiting the myopic shift in response to negative lenses, and Fast-OFF profiles inhibiting the hyperopic shift in response to positive lenses. What is unknown is whether similar sign-of-defocus dependent results produced by spatio-temporal modulation of sawtooth patterns could be achieved by rearing chicks under whole field low temporal frequency sawtooth luminance profiles at 1 or 4 Hz without a spatial component, or whether such stimuli would indiscriminately elicit a myopic shift such as that previously shown with symmetrical (or near-symmetrical) low frequency flicker across a range of species. Hatchling chicks ( Both 1 Hz and 4 Hz Fast-ON and Fast-OFF sawtooth flicker induced an increase in vitreous chamber depth that was greater in the presence of negative compared to positive lens defocus. Both sawtooth profiles at both temporal frequencies inhibited the hyperopic shift in response to +10D lenses, whilst full myopic compensation (or over-compensation) in response to -10D lenses was observed. Whole field low temporal frequency Fast-ON and Fast-OFF sawtooth flicker induces a generalized myopic shift, similar to that previously shown for symmetrical sine-wave and square-wave flicker. Our findings highlight that temporal modulation of retinal ON/OFF pathways per se (without a spatial component) is insufficient to produce strong sign-of-defocus dependent effect.
Identifiants
pubmed: 30697484
doi: 10.7717/peerj.6277
pii: 6277
pmc: PMC6347968
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e6277Déclaration de conflit d'intérêts
The authors declare there are no competing interests.
Références
Prog Retin Eye Res. 2000 Jul;19(4):421-57
pubmed: 10785617
Br J Ophthalmol. 2001 May;85(5):521-6
pubmed: 11316705
Int Rev Cytol. 2002;215:395-431
pubmed: 11952236
Neuroreport. 2002 Jun 12;13(8):1029-32
pubmed: 12060802
Neuroreport. 2003 Jul 1;14(9):1233-7
pubmed: 12824766
Ophthalmic Physiol Opt. 1992 Oct;12(4):448-56
pubmed: 1293533
J Neurophysiol. 2005 Jan;93(1):481-92
pubmed: 15331616
Zhonghua Yan Ke Za Zhi. 2004 Sep;40(9):601-4
pubmed: 15500764
Prog Retin Eye Res. 2005 Jan;24(1):1-38
pubmed: 15555525
Exp Eye Res. 2006 Aug;83(2):322-8
pubmed: 16579985
Curr Eye Res. 1990 Aug;9(8):733-40
pubmed: 1703472
Invest Ophthalmol Vis Sci. 2008 Feb;49(2):706-12
pubmed: 18235018
Ophthalmology. 2008 Aug;115(8):1279-85
pubmed: 18294691
Vision Res. 1991;31(7-8):1237-50
pubmed: 1891815
Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5348-54
pubmed: 19516016
Vision Res. 1991;31(5):833-44
pubmed: 2035267
Surv Ophthalmol. 2010 Nov-Dec;55(6):539-60
pubmed: 20850856
Ciba Found Symp. 1990;155:63-84; discussion 84-8
pubmed: 2088682
Exp Eye Res. 2011 Jan;92(1):40-6
pubmed: 21055401
Ophthalmic Res. 2011;46(2):80-7
pubmed: 21273796
Exp Eye Res. 2012 Oct;103:33-40
pubmed: 22960317
Invest Ophthalmol Vis Sci. 2013 Jan 30;54(1):890-7
pubmed: 23307951
Invest Ophthalmol Vis Sci. 2013 Feb 05;54(2):1026-33
pubmed: 23322575
Int J Ophthalmol. 2013 Apr 18;6(2):115-9
pubmed: 23638407
Exp Eye Res. 2013 Sep;114:48-57
pubmed: 23680160
Curr Eye Res. 2013 Nov;38(11):1182-90
pubmed: 23841847
Clin Exp Optom. 2014 Jan;97(1):55-61
pubmed: 23844603
Biomed Res Int. 2013;2013:761823
pubmed: 23936844
Hum Mol Genet. 2014 Jan 15;23(2):546-54
pubmed: 24014484
Eur J Epidemiol. 2013 Dec;28(12):973-80
pubmed: 24142238
Mol Vis. 2014 Sep 20;20:1318-27
pubmed: 25352740
Exp Eye Res. 2015 Aug;137:79-83
pubmed: 26072023
Vision Res. 1989;29(8):1033-6
pubmed: 2629204
Invest Ophthalmol Vis Sci. 2015 Sep;56(10):6121-31
pubmed: 26393671
PLoS One. 2015 Oct 20;10(10):e0140419
pubmed: 26485393
J Neurophysiol. 2016 May 1;115(5):2349-58
pubmed: 26888098
PLoS One. 2016 Dec 13;11(12):e0167902
pubmed: 27959948
Mol Vis. 2017 Sep 29;23:666-679
pubmed: 28966549
Ophthalmic Epidemiol. 2018 Jun;25(3):250-256
pubmed: 29281362
Iperception. 2018 Jul 12;9(4):2041669518770690
pubmed: 30083307
Vision Res. 1988;28(5):639-57
pubmed: 3195068
Invest Ophthalmol Vis Sci. 1987 Nov;28(11):1851-8
pubmed: 3667156
Vision Res. 1986;26(6):899-908
pubmed: 3750873
Doc Ophthalmol. 1985 Oct 15;60(4):327-46
pubmed: 3905312
Nature. 1977 Mar 3;266(5597):66-8
pubmed: 402582
Vision Res. 1972 Jul;12(7):1253-9
pubmed: 5047574
Invest Ophthalmol Vis Sci. 1984 Jun;25(6):652-9
pubmed: 6724835
Science. 1978 Sep 29;201(4362):1249-51
pubmed: 694514
Invest Ophthalmol Vis Sci. 1981 Apr;20(4):561-4
pubmed: 7216673
J Am Optom Assoc. 1995 Jul;66(7):405-14
pubmed: 7560727
Vision Res. 1995 May;35(9):1195-202
pubmed: 7610580
J Physiol. 1994 Mar 15;475(3):401-17
pubmed: 8006825
Invest Ophthalmol Vis Sci. 1994 May;35(6):2700-11
pubmed: 8188464
J Ocul Pharmacol Ther. 1996 Summer;12(2):193-208
pubmed: 8773935
Vision Res. 1997 Oct;37(19):2661-73
pubmed: 9373666
Ophthalmic Physiol Opt. 1997 Jul;17(4):279-90
pubmed: 9390372
Exp Eye Res. 1999 Jan;68(1):105-15
pubmed: 9986748