Effects of early life NICU stress on the developing gut microbiome.
NICU
chronic stress
early life stress
gut microbiome
preterm infants
stress
Journal
Developmental psychobiology
ISSN: 1098-2302
Titre abrégé: Dev Psychobiol
Pays: United States
ID NLM: 0164074
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
06
08
2018
revised:
11
12
2018
accepted:
12
12
2018
pubmed:
31
1
2019
medline:
13
2
2020
entrez:
31
1
2019
Statut:
ppublish
Résumé
Succession of gut microbial community structure for newborns is highly influenced by early life factors. Many preterm infants cared for in the NICU are exposed to parent-infant separation, stress, and pain from medical care procedures. The purpose of the study was to investigate the impact of early life stress on the trajectory of gut microbial structure. Stool samples from very preterm infants were collected weekly for 6 weeks. NICU stress exposure data were collected daily for 6 weeks. V4 region of the 16S rRNA gene was amplified by PCR and sequenced. Zero-inflated beta regression model with random effects was used to assess the impact of stress on gut microbiome trajectories. Week of sampling was significant for Escherichia, Staphylococcus, Enterococcus, Bifidobacterium, Proteus, Streptococcus, Clostridium butyricum, and Clostridium perfringens. Antibiotic usage was significant for Proteus, Citrobacter, and C. perfringens. Gender was significant for Proteus. Stress exposure occurring 1 and 2 weeks prior to sampling had a significant effect on Proteus and Veillonella. NICU stress exposure had a significant effect on Proteus and Veillonella. An overall dominance of Gammaproteobacteria was found. Findings suggest early life NICU stress may significantly influence the developing gut microbiome, which is important to NICU practice and future microbiome research.
Identifiants
pubmed: 30697700
doi: 10.1002/dev.21826
pmc: PMC6588487
mid: NIHMS1003605
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
650-660Subventions
Organisme : NINR NIH HHS
ID : R01 NR015446
Pays : United States
Organisme : NINR NIH HHS
ID : R21 NR013094
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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