Resolvin E1 Improves Mitochondrial Function in Human Alveolar Epithelial Cells during Severe Inflammation.

A549 Cells Alveolar Epithelial Cells / drug effects Apoptosis / drug effects Eicosapentaenoic Acid / analogs & derivatives Humans Inflammation / metabolism Mitochondria / drug effects
Fission Fusion Inflammation Lung Mitochondria Resolvin

Journal

Lipids
ISSN: 1558-9307
Titre abrégé: Lipids
Pays: United States
ID NLM: 0060450

Informations de publication

Date de publication:
01 2019
Historique:
received: 04 09 2018
revised: 21 12 2018
accepted: 23 12 2018
pubmed: 31 1 2019
medline: 3 9 2019
entrez: 31 1 2019
Statut: ppublish

Résumé

Severe inflammatory disorders such as sepsis are a major cause of morbidity and mortality worldwide. Mitochondrial dysfunction is regarded as a key feature involved in inflammation pathogenesis. In the present study, we investigated the impact of the omega-3 fatty acid-derived lipid mediator Resolvin E1 (RvE1) on mitochondrial function in experimental pulmonary inflammation. RvE1 was found to exert anti-inflammatory properties in human alveolar epithelial cells during severe inflammation. RvE1 is capable of restoring inflammation-induced mitochondrial dysfunction and the impaired imbalance of mitochondrial fission and fusion. Experimental inhibition of mitochondrial fission with Mdivi-1 in our model is associated with a significantly reduced inflammatory response and improved mitochondrial function. These findings suggest a novel functional mechanism for the beneficial effects of RvE1 in experimental pulmonary inflammatory reactions.

Identifiants

DOI: 10.1002/lipd.12119 PMID: 30697748
pubmed: 30697748
doi: 10.1002/lipd.12119
doi:

Substances chimiques

Eicosapentaenoic Acid AAN7QOV9EA
5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid GND3JH08JA

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

53-65

Informations de copyright

© 2019 AOCS.

Auteurs

Konstantin Mayer (K)

Medical Clinic II, University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University, Klinikstr. 33, 35392 Giessen, Germany.

Natascha Sommer (N)

Medical Clinic II, University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University, Klinikstr. 33, 35392 Giessen, Germany.

Karl Hache (K)

Medical Clinic II, University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University, Klinikstr. 33, 35392 Giessen, Germany.

Andreas Hecker (A)

Department of General and Thoracic Surgery, University Hospital of Giessen, Rudolf-Buchheim-Str. 7, 35392 Giessen, Germany.

Sylvia Reiche (S)

Medical Clinic II, University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University, Klinikstr. 33, 35392 Giessen, Germany.

Emmanuel Schneck (E)

Department of Anesthesiology and Intensive Care Medicine, University Hospital of Giessen, Rudolf-Buchheim-Str. 7, 35392 Giessen, Germany.

Norbert Weissmann (N)

Medical Clinic II, University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University, Klinikstr. 33, 35392 Giessen, Germany.

Werner Seeger (W)

Medical Clinic II, University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University, Klinikstr. 33, 35392 Giessen, Germany.
Max Planck Institute for Heart and Lung Research, Department of Lung Development and Remodelling, Ludwigstr. 43, 61231 Bad Nauheim, Germany.

Matthias Hecker (M)

Medical Clinic II, University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University, Klinikstr. 33, 35392 Giessen, Germany.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules A549 › Resolvin E1 Improves Mitochondrial Function in...
questionsmedicales.fr › Cellules › Cellules épithéliales › Pneumocytes › Resolvin E1 Improves Mitochondrial Function in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Resolvin E1 Improves Mitochondrial Function in...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Acide eicosapentanoïque › Resolvin E1 Improves Mitochondrial Function in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Resolvin E1 Improves Mitochondrial Function in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Resolvin E1 Improves Mitochondrial Function in...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Resolvin E1 Improves Mitochondrial Function in...