White matter has impaired resting oxygen delivery in sickle cell patients.
Journal
American journal of hematology
ISSN: 1096-8652
Titre abrégé: Am J Hematol
Pays: United States
ID NLM: 7610369
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
08
10
2018
revised:
27
12
2018
accepted:
22
01
2019
pubmed:
31
1
2019
medline:
21
12
2019
entrez:
31
1
2019
Statut:
ppublish
Résumé
Although modern medical management has lowered overt stroke occurrence in patients with sickle cell disease (SCD), progressive white matter (WM) damage remains common. It is known that cerebral blood flow (CBF) increases to compensate for anemia, but sufficiency of cerebral oxygen delivery, especially in the WM, has not been systematically investigated. Cerebral perfusion was measured by arterial spin labeling in 32 SCD patients (age range: 10-42 years old, 14 males, 7 with HbSC, 25 HbSS) and 25 age and race-matched healthy controls (age range: 15-45 years old, 10 males, 12 with HbAS, 13 HbAA); 8/24 SCD patients were receiving regular blood transfusions and 14/24 non-transfused SCD patients were taking hydroxyurea. Imaging data from control subjects were used to calculate maps for CBF and oxygen delivery in SCD patients and their T-score maps. Whole brain CBF was increased in SCD patients with a mean T-score of 0.5 and correlated with lactate dehydrogenase (r
Identifiants
pubmed: 30697803
doi: 10.1002/ajh.25423
pmc: PMC6874897
mid: NIHMS1058260
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
467-474Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL136484
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL117718
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001855
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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