Comprehensive review of 2-ethyl-1-hexanol as an indoor air pollutant.
Administration, Oral
Air Pollutants
/ adverse effects
Air Pollution, Indoor
/ adverse effects
Animals
Construction Materials
/ adverse effects
Disease Models, Animal
Floors and Floorcoverings
Hexanols
/ adverse effects
Humans
Inhalation Exposure
/ adverse effects
Mice
Plasticizers
/ adverse effects
Rats
2-ethyl-1-hexanol
emission mechanism
indoor air pollution
indoor concentration
sick building syndrome
volatile organic compounds
Journal
Journal of occupational health
ISSN: 1348-9585
Titre abrégé: J Occup Health
Pays: Australia
ID NLM: 9616320
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
17
08
2018
revised:
02
10
2018
accepted:
10
10
2018
entrez:
31
1
2019
pubmed:
31
1
2019
medline:
23
4
2019
Statut:
ppublish
Résumé
2-Ethyl-1-hexanol (2EH), a fragrance ingredient and a raw material for the production of plasticizer di(2-ethylhexyl) phthalate, is responsible for sick building syndrome (SBS). This review aims to clarify the 2EH characteristics as an indoor air pollutant such as indoor air concentration, emission mechanism, toxicity, and clinical effects. Scientific publications in English that has been made available on PubMed as of June 2018 and ad hoc publications in regional languages were reviewed. Inhalation exposure to 2EH caused mucous membrane irritation in the eyes, nose, and throat in experimental animals. Studies in human volunteers revealed an increase in olfactory irritation and eye discomfort. There has been increasing evidence of 2EH being present in indoor air in buildings. The primary sources of 2EH emissions are not building materials themselves, but instead the hydrolysis of plasticizers and flooring adhesives. In particular, compounds like di(2-ethylhexyl) phthalate present in polyvinyl chloride flooring materials are hydrolyzed upon contact with alkaline moisture-containing concrete floors. That being said, it may be observed that indoor concentrations of 2EH increased every year during summer. Unlike other volatile organic compounds that cause SBS, 2EH can be retained in indoor air for long durations, increasing the likelihood of causing undesirable health effects in building occupants exposed to it. As a precautionary measure, it is important to use flooring materials that do not emit 2EH by hydrolysis, or to dry concrete before covering with flooring materials.
Identifiants
pubmed: 30698348
doi: 10.1002/1348-9585.12017
pmc: PMC6499367
doi:
Substances chimiques
Air Pollutants
0
Hexanols
0
Plasticizers
0
2-ethylhexanol
XZV7TAA77P
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-35Subventions
Organisme : JSPS KAKENHI
ID : 16K15375
Informations de copyright
© 2019 The Authors. Journal of Occupational Health published by John Wiley & Sons Australia, Ltd on behalf of The Japan Society for Occupational Health.
Références
Toxicol In Vitro. 1991;5(3):207-10
pubmed: 20732017
Environ Sci Pollut Res Int. 2018 Mar;25(8):7113-7120
pubmed: 26099596
Chem Biol Interact. 2009 Jan 27;177(2):137-41
pubmed: 19038237
Fundam Appl Toxicol. 1996 May;31(1):29-41
pubmed: 8998951
Carcinogenesis. 1999 Jan;20(1):27-33
pubmed: 9934846
Arch Environ Health. 2004 Apr;59(4):194-201
pubmed: 16189992
Toxicology. 1992;71(1-2):49-61
pubmed: 1729767
Environ Health Perspect. 1982 Nov;45:119-25
pubmed: 6814903
Teratology. 1987 Feb;35(1):41-6
pubmed: 3105103
Arch Toxicol. 2016 Jun;90(6):1399-413
pubmed: 27037703
Fundam Appl Toxicol. 1992 Aug;19(2):176-85
pubmed: 1516773
J Occup Health. 2019 Jan;61(1):19-35
pubmed: 30698348
Biochem Pharmacol. 1992 Jun 23;43(12):2621-9
pubmed: 1632818
J Chromatogr A. 2004 Feb 13;1026(1-2):9-18
pubmed: 14870711
Environ Toxicol Pharmacol. 2005 May;19(3):531-41
pubmed: 21783523
J Environ Monit. 2006 Nov;8(11):1122-8
pubmed: 17075618
Environ Health Perspect. 1982 Nov;45:99-101
pubmed: 6754365
J Toxicol Environ Health. 1985;16(1):61-9
pubmed: 3906141
Arch Toxicol. 2016 Aug;90(8):1949-58
pubmed: 27055686
Air Waste. 1993 Mar;43(3):316-24
pubmed: 8457318
Xenobiotica. 1994 May;24(5):429-40
pubmed: 8079502
Sangyo Igaku. 1994 Nov;36(6):421-7
pubmed: 7844898
Am Ind Hyg Assoc J. 1969 Sep-Oct;30(5):470-6
pubmed: 5823428
Biochem Pharmacol. 1992 May 28;43(10):2129-34
pubmed: 1599500
Environ Int. 2008 Apr;34(3):420-7
pubmed: 17997159
J Breath Res. 2008 Sep;2(3):037023
pubmed: 21386183
Indoor Air. 2010 Apr;20(2):168-75
pubmed: 20409194
Food Chem Toxicol. 1997 May;35(5):489-500
pubmed: 9216748
Toxicol Appl Pharmacol. 1994 Jun;126(2):233-9
pubmed: 8209376
Ann Occup Hyg. 1996 Aug;40(4):397-410
pubmed: 8806212
Ann Allergy Asthma Immunol. 1997 Jun;78(6):544-54; quiz 555-6
pubmed: 9207717
Toxicol Ind Health. 1987 Jun;3(2):49-61
pubmed: 3617069
Biochem Pharmacol. 1990 Feb 15;39(4):715-21
pubmed: 2306279
J Biosci Bioeng. 2005 Feb;99(2):115-9
pubmed: 16233766
Indoor Air. 2004;14 Suppl 8:98-107
pubmed: 15663465
Indoor Air. 1999 Sep;9(3):193-201
pubmed: 10439557
J Occup Health. 2018 Jul 25;60(4):333-335
pubmed: 29984740
J Pharmacol Exp Ther. 1989 Jan;248(1):176-81
pubmed: 2913270
Environ Sci Pollut Res Int. 2015 Apr;22(8):5772-9
pubmed: 25345920
Int J Artif Organs. 2004 Nov;27(11):971-8
pubmed: 15636055
Food Chem Toxicol. 1998 Mar;36(3):165-8
pubmed: 9609389
Am Ind Hyg Assoc J. 1973 Nov;34(11):493-9
pubmed: 4770172
Xenobiotica. 1975 Oct;5(10):625-36
pubmed: 1189459
J Environ Monit. 2008 Oct;10(10):1127-33
pubmed: 18843388
Toxicology. 1983 Sep;28(1-2):167-79
pubmed: 6636199
Arch Environ Occup Health. 2010 Jan-Mar;65(1):3-11
pubmed: 20146997
Neurotoxicology. 2017 May;60:178-186
pubmed: 27545873
Acta Pharmacol Toxicol (Copenh). 1986 Mar;58(3):225-33
pubmed: 3716815
Nihon Koshu Eisei Zasshi. 2005 Dec;52(12):1021-31
pubmed: 16457196
Int Arch Occup Environ Health. 2004 Apr;77(3):222-6
pubmed: 14689309
Food Chem Toxicol. 1984 Feb;22(2):123-31
pubmed: 6538161
Nihon Eiseigaku Zasshi. 2008 Jan;63(1):20-8
pubmed: 18306654
J Environ Monit. 2009 Nov;11(11):2068-76
pubmed: 19890564
Int Arch Occup Environ Health. 1999 Oct;72(7):451-61
pubmed: 10541910
Toxicol Lett. 1982 Feb;10(2-3):273-9
pubmed: 7080097
Ecotoxicol Environ Saf. 2012 May;79:108-115
pubmed: 22236953
Environ Health Perspect. 1986 Mar;65:279-91
pubmed: 3709454
Chem Cent J. 2012 May 15;6(1):42
pubmed: 22587759
Toxicol Lett. 2003 Apr 11;140-141:261-71
pubmed: 12676473
Br J Ind Med. 1990 Nov;47(11):733-41
pubmed: 2123116
Toxicol Appl Pharmacol. 1999 Dec 1;161(2):209-18
pubmed: 10581215
Toxicol Lett. 1984 Apr;21(1):103-9
pubmed: 6719482
Indoor Air. 2000 Sep;10(3):178-92
pubmed: 10979199
Environ Toxicol Pharmacol. 2005 May;19(3):589-98
pubmed: 21783531
Chemosphere. 2006 Nov;65(9):1510-7
pubmed: 16777176
Fundam Appl Toxicol. 1992 Nov;19(4):493-7
pubmed: 1426706
Food Chem Toxicol. 1995 Nov;33(11):971-8
pubmed: 7590545
Food Chem Toxicol. 2010 Jul;48 Suppl 4:S115-29
pubmed: 20659633
Arch Environ Health. 1992 Jan-Feb;47(1):8-15
pubmed: 1540009
J Pharmacol Exp Ther. 1990 Mar;252(3):1355-60
pubmed: 2319471
Am J Ophthalmol. 1946 Nov;29(11):1363-72
pubmed: 20276971
Natl Toxicol Program Tech Rep Ser. 1982 Mar;217:1-127
pubmed: 12778218
Environ Pollut. 2006 Mar;140(1):181-5
pubmed: 16125828
Z Gesamte Hyg. 1973 Jul;19(7):485-90
pubmed: 4756688
J Environ Monit. 2007 Mar;9(3):240-5
pubmed: 17344949
Environ Mutagen. 1983;5(5):657-63
pubmed: 6352251
Mutat Res. 1982 Oct-Nov;102(3):297-304
pubmed: 6890626
Molecules. 2014 Jun 25;19(7):8707-24
pubmed: 24968328
J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Dec 12;911:84-92
pubmed: 23217311
Environ Health Perspect. 1982 Nov;45:27-34
pubmed: 6754361
Int J Tuberc Lung Dis. 2000 Nov;4(11):1016-25
pubmed: 11092713
Biochem J. 1953 Jan;53(1):137-40
pubmed: 13032045
Fundam Appl Toxicol. 1989 Feb;12(2):258-68
pubmed: 2714526
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013 Apr;56(4):590-9
pubmed: 23529606
Environ Health Perspect. 1982 Nov;45:19-25
pubmed: 7140694
Environ Health Prev Med. 2014 Mar;19(2):117-25
pubmed: 24078404
Nihon Eiseigaku Zasshi. 2009 Jan;64(1):26-31
pubmed: 19246857
Environ Health Perspect. 1982 Nov;45:35-40
pubmed: 6754363
Toxicol Lett. 1988 Jan;40(1):77-84
pubmed: 3341051
Biochem Pharmacol. 1982 Nov 1;31(21):3419-23
pubmed: 6756415
Nihon Eiseigaku Zasshi. 2011 Jan;66(1):122-8
pubmed: 21358143
Nihon Koshu Eisei Zasshi. 2010 Sep;57(9):825-34
pubmed: 21061561
Sangyo Igaku. 1994 Sep;36(5):314-23
pubmed: 7967156
PPAR Res. 2010;2010:
pubmed: 20847941
Poult Sci. 1984 Mar;63(3):469-77
pubmed: 6718301
Toxicol Lett. 1991 Jun;57(1):113-20
pubmed: 2048157
Biochem J. 1953 Jan;53(1):129-36
pubmed: 13032044
Toxicol Ind Health. 1990 May-Jul;6(3-4):373-87
pubmed: 2237924
Occup Environ Med. 1994 Oct;51(10):683-8
pubmed: 8000493
Am Ind Hyg Assoc J. 1993 Sep;54(9):488-544
pubmed: 8379496
Toxicol Appl Pharmacol. 2000 Aug 1;166(3):222-9
pubmed: 10906286
Sci Total Environ. 2017 Feb 1;579:169-178
pubmed: 27866741
Toxicol Appl Pharmacol. 1991 Feb;107(2):344-9
pubmed: 1994516
Toxicology. 1985 Mar 15;34(3):247-59
pubmed: 3883574
Toxicol Lett. 1991 Dec;59(1-3):239-44
pubmed: 1755031
Biodegradation. 2002;13(5):343-52
pubmed: 12688586
Fundam Appl Toxicol. 1996 Jan;29(1):31-9
pubmed: 8838637
Arch Environ Health. 2001 Jan-Feb;56(1):30-6
pubmed: 11256854
Neurotoxicology. 2007 Mar;28(2):347-55
pubmed: 16712936
Toxicol Appl Pharmacol. 1985 Aug;80(1):23-32
pubmed: 4024105
Indoor Air. 2007 Dec;17(6):450-7
pubmed: 18045269
Environ Health Perspect. 1982 Nov;45:111-4
pubmed: 6754360
Indoor Air. 2004 Jun;14(3):178-87
pubmed: 15104785
Sangyo Igaku. 1985 Nov;27(6):400-19
pubmed: 3913787
Biochem Pharmacol. 1977 Jan 1;26(1):19-24
pubmed: 831723
Arch Toxicol. 1992;66(5):321-6
pubmed: 1610294
Toxicol Appl Pharmacol. 1988 Aug;95(1):104-21
pubmed: 3413790
Teratog Carcinog Mutagen. 1987;7(1):29-48
pubmed: 2884741
Toxicol Lett. 1982 Mar;10(4):379-83
pubmed: 7089991
Water Res. 2004 Oct;38(17):3693-8
pubmed: 15350420
Environ Mutagen. 1983;5(2):227-31
pubmed: 6861726