Impairment of Motor Function Correlates with Neurometabolite and Brain Iron Alterations in Parkinson's Disease.
GABA
Parkinson’s disease
brain iron
magnetic resonance imaging
magnetic resonance spectroscopy
motor dysfunction
neurometabolites
spectroscopy
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
29 01 2019
29 01 2019
Historique:
received:
20
12
2018
revised:
17
01
2019
accepted:
24
01
2019
entrez:
1
2
2019
pubmed:
1
2
2019
medline:
1
2
2019
Statut:
epublish
Résumé
We took advantage of magnetic resonance imaging (MRI) and spectroscopy (MRS) as non-invasive methods to quantify brain iron and neurometabolites, which were analyzed along with other predictors of motor dysfunction in Parkinson's disease (PD). Tapping hits, tremor amplitude, and the scores derived from part III of the Movement Disorder Society-Sponsored Revision of the Unified Parkinson Disease Rating Scale (MDS-UPDRS3 scores) were determined in 35 male PD patients and 35 controls. The iron-sensitive MRI relaxation rate R2* was measured in the globus pallidus and substantia nigra. γ-aminobutyric acid (GABA)-edited and short echo-time MRS was used for the quantification of neurometabolites in the striatum and thalamus. Associations of R2*, neurometabolites, and other factors with motor function were estimated with Spearman correlations and mixed regression models to account for repeated measurements (hands, hemispheres). In PD patients, R2* and striatal GABA correlated with MDS-UPDRS3 scores if not adjusted for age. Patients with akinetic-rigid PD subtype (
Identifiants
pubmed: 30699914
pii: cells8020096
doi: 10.3390/cells8020096
pmc: PMC6406520
pii:
doi:
Substances chimiques
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIEHS NIH HHS
ID : F31 ES028081
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES020529
Pays : United States
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