The ORMDL/Orm-serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes.


Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
29 03 2019
Historique:
received: 26 12 2018
revised: 25 01 2019
pubmed: 1 2 2019
medline: 18 10 2019
entrez: 1 2 2019
Statut: ppublish

Résumé

Sphingolipids compose a lipid family critical for membrane structure as well as intra- and intercellular signaling.

Identifiants

pubmed: 30700557
pii: S0021-9258(20)35563-0
doi: 10.1074/jbc.RA118.007291
pmc: PMC6442065
doi:

Substances chimiques

Ceramides 0
Membrane Proteins 0
ORMDL3 protein, human 0
Sphingolipids 0
Adenosine Triphosphate 8L70Q75FXE
SPTLC1 protein, human EC 2.3.1.50
Serine C-Palmitoyltransferase EC 2.3.1.50

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

5146-5156

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL131340
Pays : United States

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Auteurs

Deanna L Davis (DL)

From the Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298.

Kenneth Gable (K)

the Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, and.

John Suemitsu (J)

From the Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298.

Teresa M Dunn (TM)

the Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, and.

Binks W Wattenberg (BW)

From the Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, brian.wattenberg@vcuhealth.org.
the James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40202.

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Classifications MeSH