Intrinsically disordered proteins in synaptic vesicle trafficking and release.
complexin
intrinsically disordered protein
lipid vesicle
membrane trafficking
membraneless organelles
neurotransmitter release
phase transitions
protein folding
synaptic vesicles
α-synuclein
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
08 03 2019
08 03 2019
Historique:
pubmed:
1
2
2019
medline:
8
5
2019
entrez:
1
2
2019
Statut:
ppublish
Résumé
The past few years have resulted in an increased awareness and recognition of the prevalence and roles of intrinsically disordered proteins and protein regions (IDPs and IDRs, respectively) in synaptic vesicle trafficking and exocytosis and in overall synaptic organization. IDPs and IDRs constitute a class of proteins and protein regions that lack stable tertiary structure, but nevertheless retain biological function. Their significance in processes such as cell signaling is now well accepted, but their pervasiveness and importance in other areas of biology are not as widely appreciated. Here, we review the prevalence and functional roles of IDPs and IDRs associated with the release and recycling of synaptic vesicles at nerve terminals, as well as with the architecture of these terminals. We hope to promote awareness, especially among neuroscientists, of the importance of this class of proteins in these critical pathways and structures. The examples discussed illustrate some of the ways in which the structural flexibility conferred by intrinsic protein disorder can be functionally advantageous in the context of cellular trafficking and synaptic function.
Identifiants
pubmed: 30700558
pii: S0021-9258(20)38963-8
doi: 10.1074/jbc.REV118.006493
pmc: PMC6416451
doi:
Substances chimiques
Intrinsically Disordered Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3325-3342Subventions
Organisme : NIMH NIH HHS
ID : F30 MH101982
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG019391
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117518
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG019391
Pays : United States
Informations de copyright
© 2019 Snead and Eliezer.
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