Adenoma and advanced neoplasia detection rates increase from 45 years of age.
Adenoma
/ diagnostic imaging
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Colonic Polyps
/ diagnostic imaging
Colonoscopy
/ statistics & numerical data
Colorectal Neoplasms
/ diagnostic imaging
Early Detection of Cancer
/ methods
Female
Humans
Incidence
Male
Mass Screening
/ methods
Middle Aged
Retrospective Studies
Sex Factors
Young Adult
Adenoma detection rate
Cohort study
Colonoscopy
Colorectal cancer
Screening
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
28 Jan 2019
28 Jan 2019
Historique:
received:
08
11
2018
revised:
23
12
2018
accepted:
27
12
2018
entrez:
1
2
2019
pubmed:
1
2
2019
medline:
6
4
2019
Statut:
ppublish
Résumé
Colonoscopy is considered a valid primary screening tool for colorectal cancer (CRC). The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate (ADR). Due to the fact that screening programs usually start from the age of 50, very few data are available on the risk of adenoma between 40 and 49 years. However, the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years. To compare the ADR and advanced neoplasia detection rate (ANDR) according to age in a large series of patients during routine colonoscopy. All consecutive patients who were scheduled for colonoscopy were included. Exclusion criteria were as follows: patients scheduled for partial colonoscopy or interventional colonoscopy (for stent insertion or stenosis dilation). Colonoscopies were performed in our unit by a team of 30 gastroenterologists in 2016. We determined the ADR and ANDR in each age group in the whole population and in the population with an average risk of CRC (excluding patients with personal or family history of advanced adenoma or cancer). 6027 colonoscopies were performed in patients with a median age of 57 years (range, 15-96). The ADR and ANDR were 28.6% and 9.7%, respectively, in the whole population. When comparing patients aged 40-44 ( This study shows a significant two-fold increase in the ADR and ANDR in patients aged 45 years and over.
Sections du résumé
BACKGROUND
BACKGROUND
Colonoscopy is considered a valid primary screening tool for colorectal cancer (CRC). The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate (ADR). Due to the fact that screening programs usually start from the age of 50, very few data are available on the risk of adenoma between 40 and 49 years. However, the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years.
AIM
OBJECTIVE
To compare the ADR and advanced neoplasia detection rate (ANDR) according to age in a large series of patients during routine colonoscopy.
METHODS
METHODS
All consecutive patients who were scheduled for colonoscopy were included. Exclusion criteria were as follows: patients scheduled for partial colonoscopy or interventional colonoscopy (for stent insertion or stenosis dilation). Colonoscopies were performed in our unit by a team of 30 gastroenterologists in 2016. We determined the ADR and ANDR in each age group in the whole population and in the population with an average risk of CRC (excluding patients with personal or family history of advanced adenoma or cancer).
RESULTS
RESULTS
6027 colonoscopies were performed in patients with a median age of 57 years (range, 15-96). The ADR and ANDR were 28.6% and 9.7%, respectively, in the whole population. When comparing patients aged 40-44 (
CONCLUSION
CONCLUSIONS
This study shows a significant two-fold increase in the ADR and ANDR in patients aged 45 years and over.
Identifiants
pubmed: 30700941
doi: 10.3748/wjg.v25.i4.447
pmc: PMC6350166
doi:
Types de publication
Comparative Study
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
447-456Déclaration de conflit d'intérêts
Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.
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