Basic clinical features do not predict dopamine transporter binding in idiopathic REM behavior disorder.
Journal
NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390
Informations de publication
Date de publication:
2019
2019
Historique:
received:
06
07
2018
accepted:
03
12
2018
entrez:
1
2
2019
pubmed:
1
2
2019
medline:
1
2
2019
Statut:
epublish
Résumé
REM sleep behavior disorder (RBD) is strongly associated with development of Parkinson's Disease and other α-synuclein-related disorders. Dopamine transporter (DAT) binding deficit predicts conversion to α-synuclein-related disorders in individuals with RBD. In turn, identifying which individuals with RBD have the highest likelihood of having abnormal DAT binding would be useful. The objective of this analysis was to examine if there are basic clinical predictors of DAT deficit in RBD. Participants referred for inclusion in the RBD cohort of the Parkinson Progression Markers Initiative were included. Assessments at the screening visit including DAT SPECT imaging, physical examination, cognitive function screen, and questionnaire-based non-motor assessment. The group with DAT binding deficit (
Identifiants
pubmed: 30701189
doi: 10.1038/s41531-018-0073-1
pii: 73
pmc: PMC6351563
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2Investigateurs
B Kumar
(B)
L James
(L)
G Nomikos
(G)
J Cedarbaum
(J)
M Yang
(M)
M Brys
(M)
V Irzhevesky
(V)
K Schmidt
(K)
N Jennings
(N)
A Reith
(A)
D Tattersall
(D)
M Sanchez
(M)
N Daegele
(N)
C Min
(C)
R Malkani
(R)
J Peterschmitt
(J)
P Sardi
(P)
S Bozzi
(S)
T Fischer
(T)
R Evans
(R)
V Kiyasova
(V)
A Simen
(A)
A Siderowf
(A)
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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