Back to the Colorectal Cancer Consensus Molecular Subtype Future.
CMS
Colorectal cancer
Consensus molecular subtypes
RNAseq
Journal
Current gastroenterology reports
ISSN: 1534-312X
Titre abrégé: Curr Gastroenterol Rep
Pays: United States
ID NLM: 100888896
Informations de publication
Date de publication:
30 Jan 2019
30 Jan 2019
Historique:
entrez:
1
2
2019
pubmed:
1
2
2019
medline:
29
5
2019
Statut:
epublish
Résumé
This review seeks to provide an informed prospective on the advances in molecular profiling and analysis of colorectal cancer (CRC). The goal is to provide a historical context and current summary on how advances in gene and protein sequencing technology along with computer capabilities led to our current bioinformatic advances in the field. An explosion of knowledge has occurred regarding genetic, epigenetic, and biochemical alterations associated with the evolution of colorectal cancer. This has led to the realization that CRC is a heterogeneous disease with molecular alterations often dictating natural history, response to treatment, and outcome. The consensus molecular subtypes (CMS) classification classifies CRC into four molecular subtypes with distinct biological characteristics, which may form the basis for clinical stratification and subtype-based targeted intervention. This review summarizes new developments of a field moving "Back to the Future." CRC molecular subtyping will better identify key subtype specific therapeutic targets and responses to therapy.
Identifiants
pubmed: 30701321
doi: 10.1007/s11894-019-0674-9
pii: 10.1007/s11894-019-0674-9
pmc: PMC6622456
mid: NIHMS1039672
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA221707
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA177909
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA172670
Pays : United States
Organisme : NCI NIH HHS
ID : UH2 CA207101
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA178744
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA184843
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA187238
Pays : United States
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