Associations between vertebral body fat fraction and intervertebral disc biochemical composition as assessed by quantitative MRI.
Adipose Tissue
/ diagnostic imaging
Adolescent
Adult
Aged
Cross-Sectional Studies
Female
Humans
Intervertebral Disc
/ diagnostic imaging
Intervertebral Disc Degeneration
/ diagnostic imaging
Lumbar Vertebrae
/ diagnostic imaging
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Prospective Studies
Young Adult
bone marrow fat
chronic lower back pain
intervertebral disc degeneration
spine
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
07
11
2018
revised:
16
01
2019
accepted:
17
01
2019
pubmed:
1
2
2019
medline:
21
10
2020
entrez:
1
2
2019
Statut:
ppublish
Résumé
There is an interplay between the intervertebral disc (IVD) and the adjacent bone marrow that may play a role in the development of IVD degeneration and might influence chronic lower back pain (CLBP). To apply novel quantitative MRI techniques to assess the relationship between vertebral bone marrow fat (BMF) and biochemical changes in the adjacent IVD. Prospective. Forty-six subjects (26 female and 20 male) with a mean age of 47.3 ± 12.0 years. 3 T MRI; a combined T Using quantitative MRI, the vertebral BMF fraction was measured as well as the biochemical composition (proteoglycan and collagen content) of the IVD. Furthermore, clinical Pfirrmann grading, Oswestry disability index (ODI), and visual analog scale (VAS) was assessed. Mixed random effects models accounting for multiple measurements per subject were used to assess the relationships between disc measurements and BMF. The relationships between BMF (mean) and T Our study demonstrates significant associations between BMF and biochemical changes in the adjacent IVD, both assessed by quantitative MRI; this may suggest that the conversion of hematopoietic bone marrow to fatty bone marrow impairs the supply of available nutrients to cells in the IVD and may thereby accelerate disc degeneration. 2 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019;50:1219-1226.
Sections du résumé
BACKGROUND
There is an interplay between the intervertebral disc (IVD) and the adjacent bone marrow that may play a role in the development of IVD degeneration and might influence chronic lower back pain (CLBP).
PURPOSE
To apply novel quantitative MRI techniques to assess the relationship between vertebral bone marrow fat (BMF) and biochemical changes in the adjacent IVD.
STUDY TYPE
Prospective.
SUBJECTS
Forty-six subjects (26 female and 20 male) with a mean age of 47.3 ± 12.0 years.
FIELD STRENGTH/SEQUENCE
3 T MRI; a combined T
ASSESSMENT
Using quantitative MRI, the vertebral BMF fraction was measured as well as the biochemical composition (proteoglycan and collagen content) of the IVD. Furthermore, clinical Pfirrmann grading, Oswestry disability index (ODI), and visual analog scale (VAS) was assessed.
STATISTICAL TESTS
Mixed random effects models accounting for multiple measurements per subject were used to assess the relationships between disc measurements and BMF.
RESULTS
The relationships between BMF (mean) and T
DATA CONCLUSION
Our study demonstrates significant associations between BMF and biochemical changes in the adjacent IVD, both assessed by quantitative MRI; this may suggest that the conversion of hematopoietic bone marrow to fatty bone marrow impairs the supply of available nutrients to cells in the IVD and may thereby accelerate disc degeneration.
LEVEL OF EVIDENCE
2 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019;50:1219-1226.
Identifiants
pubmed: 30701594
doi: 10.1002/jmri.26675
pmc: PMC6667309
mid: NIHMS1018431
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1219-1226Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR066262
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR063705
Pays : United States
Organisme : NIAMS NIH HHS
ID : R56 AR063705
Pays : United States
Informations de copyright
© 2019 International Society for Magnetic Resonance in Medicine.
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