Impact of a non-fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries-susceptible orthodontic patients: A randomized, controlled 6-month trial.
dentifrice
enamel caries
fluoride
hydroxyapatite
orthodontic therapy
Journal
Journal of investigative and clinical dentistry
ISSN: 2041-1626
Titre abrégé: J Investig Clin Dent
Pays: Australia
ID NLM: 101524471
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
31
07
2018
accepted:
30
11
2018
pubmed:
1
2
2019
medline:
27
11
2019
entrez:
1
2
2019
Statut:
ppublish
Résumé
The aim of the present randomized, controlled trial was to compare the impact of the regular use of a fluoride-free microcrystalline hydroxyapatite (HAP) dentifrice and a 1400 ppm fluoride control dentifrice on caries progression in 150 highly caries-active orthodontic patients. The primary outcome was the occurrence of lesions with International Caries Detection and Assessment System (ICDAS) ≥code 1 on the vestibular surfaces of teeth 15-25 within 168 days after fixation of orthodontic brackets. Secondary outcomes were lesion development ICDAS ≥code 2, the plaque index, and the gingival index. In total, 147 patients were included in the intent-to-treat (ITT) analysis; 133 finished the study per protocol (PP). An increase in enamel caries ICDAS ≥code 1 was observed in 56.8% (ITT) and 54.7% (PP) of the HAP group participants compared with 60.9% (ITT) and 61.6% (PP) of the fluoride control group. Non-inferiority testing (ITT and PP) demonstrated the absence of a significant difference between the groups. No significant differences in secondary outcomes were observed between the groups. In highly caries-active patients, the impact of the regular use of a microcrystalline HAP dentifrice on caries progression is not significantly different from the use of a 1400 ppm fluoride toothpaste (ClinicalTrials.gov: NCT02705456).
Identifiants
pubmed: 30701704
doi: 10.1111/jicd.12399
pmc: PMC6590169
doi:
Substances chimiques
Cariostatic Agents
0
Dentifrices
0
Hydroxyapatites
0
Toothpastes
0
Fluorides
Q80VPU408O
Banques de données
ClinicalTrials.gov
['NCT02705456']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12399Subventions
Organisme : Dr. Kurt Wolff GmbH & Co. KG, Bielefeld, Germany
Informations de copyright
© 2019 The Authors Journal of Investigative and Clinical Dentistry Published by John Wiley & Sons Australia, Ltd.
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