Association of Vitamin D Receptor Gene Polymorphism With the Risk of Nephrolithiasis.
Gene polymorphism
Nephrolithiasis
Pooled-analysis
Vitamin D receptor
Journal
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
ISSN: 1744-9987
Titre abrégé: Ther Apher Dial
Pays: Australia
ID NLM: 101181252
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
24
09
2018
revised:
04
12
2018
accepted:
29
01
2019
pubmed:
1
2
2019
medline:
23
2
2020
entrez:
1
2
2019
Statut:
ppublish
Résumé
This study aimed to explore the relationship between vitamin D receptor (VDR) gene polymorphisms and the risk of nephrolithiasis. All relevant trials were searched from multiple databases according to predefined criteria, the pooled OR and corresponding 95% CI were analyzed using Stata software. Seventeen studies involving 2441 cases and 2296 controls were included. The pooled analysis showed that VDR BsmI, FokI, and ApaI gene polymorphisms were not associated with nephrolithiasis susceptibility either in Asian and in Caucasians populations. VDR TaqI gene polymorphism was associated with nephrolithiasis in the overall populations (T vs. t: OR = 0.84, 95% CI: 0.73-0.95, P = 0.006; TT vs. Tt + tt: OR = 0.79, 95% CI: 0.66-0.95, P = 0.010). In Asian population, VDR TaqI gene polymorphism also was associated with nephrolithiasis susceptibility (TT vs. Tt + tt: OR = 0.72, 95% CI: 0.55-0.93, P = 0.012; Tt vs. TT + tt: OR = 1.43, 95% CI: 1.00-2.05, P = 0.048). But TaqI gene polymorphism was not associated with nephrolithiasis risk in Caucasian populations (T vs. t: OR = 0.85, 95% CI: 0.72-1.00, P = 0.051; TT vs. Tt + tt: OR = 0.87, 95% CI: 0.68-1.10, P = 0.245; tt vs. Tt + TT: OR = 1.32, 95% CI: 0.86-2.01, P = 0.206; Tt vs. TT+ tt: OR = 0.98, 95% CI: 0.70-1.38, P = 0.931). VDR BsmI, FokI, and ApaI gene polymorphisms were not associated with the risk of nephrolithiasis either in Asian and Caucasians populations, but VDR TaqI gene polymorphism was associated with nephrolithiasis in the Asian subjects.
Identifiants
pubmed: 30701705
doi: 10.1111/1744-9987.12797
doi:
Substances chimiques
Receptors, Calcitriol
0
VDR protein, human
0
Types de publication
Journal Article
Meta-Analysis
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
425-436Subventions
Organisme : National Natural Sciences Foundation of China
ID : 81500558, 81600566
Organisme : Natural Sciences Foundation of Hunan province
ID : 2018JJ3785
Organisme : The New Xiangya Talent Project, Third Xiangya Hospital of Central South University
ID : JY201521
Organisme : Zhejiang Natural Science Foundation
ID : LQ16H050001
Informations de copyright
© 2019 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.
Références
Sakhaee K. Recent advances in the pathophysiology of nephrolithiasis. Kidney Int 2009;75:585-95.
Aggarwal KP, Narula S, Kakkar M, Tandon C. Nephrolithiasis: molecular mechanism of renal stone formation and the critical role played by modulators. Biomed Res Int 2013;2013:292953.
Sayer JA. Progress in understanding the genetics of calcium-containing nephrolithiasis. J Am Soc Nephrol 2017;28:748-59.
Vezzoli G, Terranegra A, Arcidiacono T, Soldati L. Genetics and calcium nephrolithiasis. Kidney Int 2011;80:587-93.
Tang J, Chonchol MB. Vitamin D and kidney stone disease. Curr Opin Nephrol Hypertens 2013;22:383-9.
Letavernier E, Daudon M. Vitamin D, hypercalciuria and kidney stones. Nutrients 2018;10.
Kahwati LC, Weber RP, Pan H et al. Vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults: evidence report and systematic review for the US preventive services task force. JAMA 2018;319:1600-12.
Pike JW. Vitamin D3 receptors: structure and function in transcription. Annu Rev Nutr 1991;11:189-216.
Vezzoli G, Soldati L, Proverbio MC et al. Polymorphism of vitamin D receptor gene start codon in patients with calcium kidney stones. J Nephrol 2002;15:158-64.
Ferreira LG, Pereira AC, Heilberg IP. Vitamin D receptor and calcium-sensing receptor gene polymorphisms in hypercalciuric stone-forming patients. Nephron Clin Pract 2010;114:c135-44.
Aykan S, Tuken M, Gunes S et al. ApaL1 urokinase and Taq1 vitamin D receptor gene polymorphisms in first-stone formers, recurrent stone formers, and controls in a Caucasian population. Urolithiasis 2016;44:109-15.
Goknar N, Oktem F, Torun E et al. The role of vitamin D receptor gene polymorphisms in Turkish infants with urolithiasis. Ren Fail 2016;38:545-51.
Zhou TB, Jiang ZP, Li AH, Ju L. Association of vitamin D receptor BsmI (rs1544410), Fok1 (rs2228570), TaqI (rs731236) and ApaI (rs7975232) gene polymorphism with the nephrolithiasis susceptibility. J Recept Signal Transduct Res 2015;35:107-14.
Ruggiero M, Pacini S, Amato M, Aterini S, Chiarugi V. Association between vitamin D receptor gene polymorphism and nephrolithiasis. Miner Electrolyte Metab 1999;25:185-90.
Emigh TH. A comparison of tests for Hardy-Weinberg equilibrium. Biometrics 1980;36:627-42.
Bid HK, Chaudhary H, Mittal RD. Association of vitamin-D and calcitonin receptor gene polymorphism in paediatric nephrolithiasis. Pediatr Nephrol 2005;20:773-6.
Cakir OO, Yilmaz A, Demir E, Incekara K, Kose MO, Ersoy N. Association of the BsmI, ApaI, TaqI, Tru9I and FokI polymorphisms of the vitamin D receptor gene with nephrolithiasis in the Turkish population. Urol J 2016;13:2509-18.
Chen WC, Chen HY, Lu HF, Hsu CD, Tsai FJ. Association of the vitamin D receptor gene start codon Fok I polymorphism with calcium oxalate stone disease. BJU Int 2001;87:168-71.
Guha M, Bankura B, Ghosh S et al. Polymorphisms in CaSR and CLDN14 genes associated with increased risk of kidney stone disease in patients from the eastern part of India. PLoS One 2015;10:e0130790.
Gunes S, Bilen CY, Kara N, Asci R, Bagci H, Yilmaz AF. Vitamin D receptor gene polymorphisms in patients with urolithiasis. Urol Res 2006;34:47-52.
Mittal RD, Mishra DK, Srivastava P, Manchanda P, Bid HK, Kapoor R. Polymorphisms in the vitamin D receptor and the androgen receptor gene associated with the risk of urolithiasis. Indian J Clin Biochem 2010;25:119-26.
Mossetti G, Rendina D, Viceconti R et al. The relationship of 3′ vitamin D receptor haplotypes to urinary supersaturation of calcium oxalate salts and to age at onset and familial prevalence of nephrolithiasis. Nephrol Dial Transplant 2004;19:2259-65.
Nishijima S, Sugaya K, Naito A, Morozumi M, Hatano T, Ogawa Y. Association of vitamin D receptor gene polymorphism with urolithiasis. J Urol 2002;167:2188-91.
Ozkaya O, Soylemezoglu O, Misirlioglu M, Gonen S, Buyan N, Hasanoglu E. Polymorphisms in the vitamin D receptor gene and the risk of calcium nephrolithiasis in children. Eur Urol 2003;44:150-4.
Rendina D, Mossetti G, Viceconti R et al. Association between vitamin D receptor gene polymorphisms and fasting idiopathic hypercalciuria in recurrent stone-forming patients. Urology 2004;64:833-8.
Wang S, Wang X, Wu J et al. Association of vitamin D receptor gene polymorphism and calcium urolithiasis in the Chinese Han population. Urol Res 2012;40:277-84.
Hu SQ, Liu JH, Wang SG, Cao ZG, Wu Wei. Relationship between vitamin D receptor allele polymorphism and calcium oxalate stone disease. Chin J Urol 2004;25:155-8.
Li ZM, Ruan L, Shi GQ, et al. Association between single nucleofide polymorphism of vitamin D receptor start codon Fok I and urinary calcium level. Chin J Biomed Eng 2010;16:38-41.
Kaysar AJI, Song GL, Anwar YASEN, et al. Association of vitamin D receptor gene polymorphisms with urolithiasis in Uyghur children from southern Xinjiang, China. Chin J Contemp Pediatr 2012;14:956-9.
Xu C, Song RJ, Wang XL, et al. The association among vitamin D receptor gene, Klotho gene poIymorpllisms and calcium Uthiasis. Chin J Exp Surg 2013;30:2554-7.
Subasi B, Gokce I, Delil K, Alpay H. Vitamin D receptor gene polymorphisms in children with kidney stone disease. Turk J Pediatr 2017;59:404-9.
Basiri A, Shakhssalim N, Houshmand M et al. Coding region analysis of vitamin D receptor gene and its association with active calcium stone disease. Urol Res 2012;40:35-40.
Bid HK, Kumar A, Kapoor R, Mittal RD. Association of vitamin D receptor-gene (FokI) polymorphism with calcium oxalate nephrolithiasis. J Endourol 2005;19:111-5.
Jackman SV, Kibel AS, Ovuworie CA, Moore RG, Kavoussi LR, Jarrett TW. Familial calcium stone disease: TaqI polymorphism and the vitamin D receptor. J Endourol 1999;13:313-6.
Mossetti G, Vuotto P, Rendina D et al. Association between vitamin D receptor gene polymorphisms and tubular citrate handling in calcium nephrolithiasis. J Intern Med 2003;253:194-200.
Relan V, Khullar M, Singh SK, Sharma SK. Association of vitamin D receptor genotypes with calcium excretion in nephrolithiatic subjects in northern India. Urol Res 2004;32:236-40.
Seo IY, Kang IH, Chae SC et al. Vitamin D receptor gene Alw I, Fok I, Apa I, and Taq I polymorphisms in patients with urinary stone. Urology 2010;75:923-7.
Seyhan S, Yavascaoglu I, Kilicarslan H, Dogan HS, Kordan Y. Association of vitamin D receptor gene Taq I polymorphism with recurrent urolithiasis in children. Int J Urol 2007;14:1060-2.
Guo AJ, Qian B, Ding GF, Wang QZ. Association of vitamin D receptor ApaI gene polymorphism and calcium urolithiasis in the XinJiang Province. J Nongken Med 2009;31:4-6.
Ruan L, Li ZM, Zheng RG, et al. Association of vitamin D receptor FokI gene polymorphism and calcium urolithiasis in the Guangzhou City. Guangdong Med J 2012;33:84-5.
Wang QZ, Qian B, Ding GF, Zhen LY. Vitamin D receptor gene polymorphisms in Chinese uygur patients with urolithiasis in South Xinjiang. J Pract Med 2009;25:2805-7.
Zhang P, Nie W, Jiang H. Effects of vitamin D receptor polymorphisms on urolithiasis risk: a meta-analysis. BMC Med Genet 2013;14:104.
Iqbal MUN, Khan TA. Association between vitamin D receptor (Cdx2, Fok1, Bsm1, Apa1, Bgl1, Taq1, and Poly (A)) gene polymorphism and breast cancer: a systematic review and meta-analysis. Tumour Biol 2017;39:1010428317731280.
Li L, Wan Q, Yang S, Zhao S. Impact of vitamin D receptor gene polymorphism on chronic renal failure susceptibility. Ther Apher Dial 2018;22:575-87.
Jia J, Ding H, Yang K et al. Vitamin D receptor genetic polymorphism is significantly associated with risk of type 2 diabetes mellitus in Chinese Han population. Arch Med Res 2015;46:572-9.
Ou C, Zhao HL, Zhu B, Huang LS, Li PZ, Lao M. Association of vitamin D receptor gene polymorphism with the risk of renal cell carcinoma: a meta-analysis. J Recept Signal Transduct Res 2014;34:463-8.
van Etten E, Verlinden L, Giulietti A et al. The vitamin D receptor gene FokI polymorphism: functional impact on the immune system. Eur J Immunol 2007;37:395-405.
Mirfeizi Z, Tabaei S, Ravanshad Y, Hashemzadeh K, Kharazmi E, Mehrad-Majd H. Associations between vitamin D receptor polymorphisms and susceptibility to Behcet's disease: a meta-analysis. Immunol Invest 2018;47:389-402.
Berg AO, Jorgensen KN, Nerhus M et al. Vitamin D levels, brain volume, and genetic architecture in patients with psychosis. PLoS One 2018;13:e0200250.
Hu W, Niu G, Lin Y, Chen X, Lin L. Impact of the polymorphism in vitamin D receptor gene BsmI and the risk of systemic lupus erythematosus: an updated meta-analysis. Clin Rheumatol 2016;35:927-34.
Trohatou O, Tsilibary EF, Charonis A, Iatrou C, Drossopoulou G. Vitamin D3 ameliorates podocyte injury through the nephrin signalling pathway. J Cell Mol Med 2017;21:2599-609.
Li XQ, Tembe V, Horwitz GM, Bushinsky DA, Favus MJ. Increased intestinal vitamin D receptor in genetic hypercalciuric rats. A cause of intestinal calcium hyperabsorption. J Clin Invest 1993;91:661-7.
Tsuruoka S, Bushinsky DA, Schwartz GJ. Defective renal calcium reabsorption in genetic hypercalciuric rats. Kidney Int 1997;51:1540-7.
Celeste AJ, Rosen V, Buecker JL, Kriz R, Wang EA, Wozney JM. Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. EMBO J 1986;5:1885-90.
Yasui T, Fujita K, Sasaki S et al. Expression of bone matrix proteins in urolithiasis model rats. Urol Res 1999;27:255-61.
Zhou TB, Jiang ZP, Huang MF, Zhang R. Association of vitamin D receptor gene polymorphism with the urine calcium level in nephrolithiasis patients. J Recept Signal Transduct Res 2015;35:127-32.
Whitfield GK, Remus LS, Jurutka PW et al. Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Mol Cell Endocrinol 2001;177:145-59.
Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP. Genetics and biology of vitamin D receptor polymorphisms. Gene 2004;338:143-56.
Apolihin OI, Sivkov AV, Konstantinova OV, Slominskij PA, Tupicyna TV, Kalinichenko DN. Genetic risk factors for multiple kidney stone formation in the Russian population. Urologiia 2015:4-6.