NK-lysin from skin-secreted mucus of Atlantic salmon and its potential role in bacteriostatic activity.
Antimicrobial peptides
Hepcidin
Innate immune system
NK-lysin
Salmo salar
Serum
Skin mucus
Journal
Fish & shellfish immunology
ISSN: 1095-9947
Titre abrégé: Fish Shellfish Immunol
Pays: England
ID NLM: 9505220
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
07
11
2018
revised:
24
01
2019
accepted:
25
01
2019
pubmed:
1
2
2019
medline:
3
7
2019
entrez:
1
2
2019
Statut:
ppublish
Résumé
NK-lysin, despite being a direct effector of cytotoxic T and natural killer cells, is an antimicrobial peptide (AMP) with known antibacterial function in vertebrates and so in fish. Its presence has been described in different tissues of teleost fish. One of the strongest antimicrobial barriers in fish is skin-secreted mucus; however, this mucus has been found to contain only a small number of AMPs. The present study describes for the first time the constitutive expression of NK-lysin in Atlantic salmon (Salmo salar) mucus produced by the skin, recording the AMP at a higher concentration than in serum with greater bacteriostatic activity. Hepcidin may be involved to a greater extent in systemic responses since it was expressed to a higher degree in serum which was more potent for alternative complement and peroxidase activities.
Identifiants
pubmed: 30703553
pii: S1050-4648(19)30050-6
doi: 10.1016/j.fsi.2019.01.034
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Hepcidins
0
NK-lysin
0
Proteolipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
410-413Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.