A Genetic Score of Predisposition to Low-Grade Inflammation Associated with Obesity May Contribute to Discern Population at Risk for Metabolic Syndrome.
Adult
Anti-Inflammatory Agents
/ pharmacology
Biomarkers
/ blood
Docosahexaenoic Acids
/ pharmacology
Eicosapentaenoic Acid
/ pharmacology
Female
Gene Expression Regulation
Genetic Predisposition to Disease
Genotype
Humans
Inflammation
/ blood
Male
Metabolic Syndrome
/ genetics
Obesity
/ genetics
Odds Ratio
Risk Factors
Young Adult
genetic score
low-grade inflammation
metabolic syndrome
obesity
type 2 diabetes
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
30 Jan 2019
30 Jan 2019
Historique:
received:
29
11
2018
revised:
16
01
2019
accepted:
24
01
2019
entrez:
2
2
2019
pubmed:
2
2
2019
medline:
4
4
2019
Statut:
epublish
Résumé
Omega-3 rich diets have been shown to improve inflammatory status. However, in an ex vivo system of human blood cells, the efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) modulating lipid metabolism and cytokine response is attenuated in overweight subjects and shows high inter-individual variability. This suggests that obesity may be exerting a synergistic effect with genetic background disturbing the anti-inflammatory potential of omega-3 long-chain polyunsaturated fatty acids (PUFA). In the present work, a genetic score aiming to explore the risk associated to low grade inflammation and obesity (LGI-Ob) has been elaborated and assessed as a tool to contribute to discern population at risk for metabolic syndrome. Pro-inflammatory gene expression and cytokine production as a response to omega-3 were associated with LGI-Ob score; and lower anti-inflammatory effect of PUFA was observed in subjects with a high genetic score. Furthermore, overweight/obese individuals showed positive correlation of both plasma C-Reactive Protein and triglyceride/HDLc-index with LGI-Ob; and high LGI-Ob score was associated with greater hypertension (
Identifiants
pubmed: 30704070
pii: nu11020298
doi: 10.3390/nu11020298
pmc: PMC6412420
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Biomarkers
0
Docosahexaenoic Acids
25167-62-8
Eicosapentaenoic Acid
AAN7QOV9EA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Economía y Competitividad
ID : INTERBIOBES-AGL2015-67019-P
Références
Nutrition. 2017 May;37:86-91
pubmed: 28359369
PLoS Genet. 2009 Nov;5(11):e1000730
pubmed: 19936222
Curr Cardiol Rep. 2013 Sep;15(9):400
pubmed: 23881582
Clin Chem. 1972 Jun;18(6):499-502
pubmed: 4337382
Lipids. 2010 May;45(5):375-84
pubmed: 20364438
Diabetes Metab J. 2016 Jun;40(3):222-9
pubmed: 27352253
J Nutr. 2007 Sep;137(9):2024-8
pubmed: 17709437
Curr Hypertens Rep. 2018 Feb 26;20(2):12
pubmed: 29480368
Exp Clin Endocrinol Diabetes. 2009 Jun;117(6):241-50
pubmed: 19358089
J Nutrigenet Nutrigenomics. 2009;2(3):140-8
pubmed: 19776641
PLoS One. 2011 Jan 05;6(1):e15958
pubmed: 21246032
Nat Rev Immunol. 2016 Jan;16(1):51-67
pubmed: 26688348
Obesity (Silver Spring). 2009 Feb;17(2):330-4
pubmed: 18948966
Nutr Hosp. 2015 May 01;31(5):2115-21
pubmed: 25929382
Postgrad Med J. 2017 Apr;93(1098):209-214
pubmed: 27559091
Annu Rev Nutr. 2017 Aug 21;37:395-422
pubmed: 28715990
Br J Nutr. 2011 Oct;106(8):1263-72
pubmed: 21736829
JAMA Cardiol. 2018 Mar 1;3(3):225-234
pubmed: 29387889
ISRN Nutr. 2014 Jan 01;2014:820524
pubmed: 24967273
Science. 2007 May 11;316(5826):889-94
pubmed: 17434869
J Hypertens. 2003 Nov;21(11):1983-92
pubmed: 14597836
Diabetologia. 2011 Apr;54(4):803-11
pubmed: 21181397
Cell Metab. 2014 Jul 1;20(1):103-18
pubmed: 24930973
Diabetes. 2013 Jun;62(6):1945-56
pubmed: 23349501
PLoS One. 2012;7(12):e50931
pubmed: 23251403
Nat Genet. 2015 Jun;47(6):589-97
pubmed: 25961943
Nutrients. 2017 Aug 22;9(8):
pubmed: 28829397
PLoS Genet. 2012 May;8(5):e1002741
pubmed: 22693455
Ann Pharmacother. 2018 Aug;52(8):801-809
pubmed: 29557210
J Lipid Res. 2005 Nov;46(11):2347-55
pubmed: 16150820
Am J Clin Nutr. 2016 Apr;103(4):1162-70
pubmed: 26888713
Best Pract Res Clin Endocrinol Metab. 2012 Apr;26(2):211-26
pubmed: 22498250
Mol Aspects Med. 2017 Dec;58:83-92
pubmed: 28341541
Nutrients. 2017 Oct 25;9(11):
pubmed: 29068398
N Engl J Med. 2018 Oct 18;379(16):1540-1550
pubmed: 30146932
Nutr Metab (Lond). 2016 Jan 19;13:3
pubmed: 26788114
Free Radic Res. 2014 Feb;48(2):190-9
pubmed: 24164232
Mol Nutr Food Res. 2014 Jul;58(7):1519-27
pubmed: 24753491
Diabetes Care. 2011 Aug;34(8):1869-74
pubmed: 21730284
Circulation. 2008 Feb 12;117(6):798-805
pubmed: 18212290
J Lipid Res. 2015 Sep;56(9):1774-80
pubmed: 26136510
Int J Mol Sci. 2016 Oct 09;17(10):
pubmed: 27735847
Circulation. 2006 May 2;113(17):2062-70
pubmed: 16636175
Int J Mol Sci. 2016 Mar 15;17(3):375
pubmed: 26999109
J Clin Endocrinol Metab. 2009 Apr;94(4):1451-7
pubmed: 19158204
Cytokine. 2018 Oct;110:131-136
pubmed: 29734056
Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S121-S126
pubmed: 28043815
BMC Med Genet. 2011 Sep 24;12:123
pubmed: 21943158
Clin Endocrinol (Oxf). 2018 Jan;88(1):51-57
pubmed: 29044636
Exp Gerontol. 2016 Oct;83:56-62
pubmed: 27477483
Lancet Diabetes Endocrinol. 2018 Mar;6(3):223-236
pubmed: 28919064
Eur J Nutr. 2016 Feb;55(1):247-55
pubmed: 25644180
Genet Mol Res. 2015 Oct 21;14(4):12993-3002
pubmed: 26505452
Clin Chem. 2007 Jun;53(6):1144-52
pubmed: 17446329
Br J Nutr. 2017 Jun;117(12):1663-1673
pubmed: 28633686
J Nutr. 2009 Mar;139(3):439-46
pubmed: 19141698
J Clin Endocrinol Metab. 2011 Jul;96(7):E1142-7
pubmed: 21525158
J Nutr Biochem. 2015 Apr;26(4):398-407
pubmed: 25660595
Pulse (Basel). 2016 Apr;3(3-4):217-28
pubmed: 27195243
Nature. 2017 Feb 8;542(7640):177-185
pubmed: 28179656
PLoS One. 2017 Nov 28;12(11):e0188382
pubmed: 29182660
Biomed Res Int. 2018 Aug 26;2018:5086869
pubmed: 30225256
Nat Rev Immunol. 2011 Feb;11(2):98-107
pubmed: 21233852
Pharmacogenomics J. 2016 Nov;16(6):501-506
pubmed: 26882122
Mol Nutr Food Res. 2017 Apr;61(4):
pubmed: 27873461
J Nutr. 2011 Dec;141(12):2219-25
pubmed: 22049296
Nutrients. 2015 Aug 03;7(8):6281-93
pubmed: 26247960
PLoS One. 2011;6(6):e20555
pubmed: 21674002
Biogerontology. 2015 Oct;16(5):621-30
pubmed: 25753816
Front Genet. 2014 Jul 21;5:225
pubmed: 25101110
Am J Clin Nutr. 2008 Oct;88(4):941-9
pubmed: 18842780
Compr Rev Food Sci Food Saf. 2018 Jul;17(4):1006-1020
pubmed: 33350108
Metabolites. 2014 Apr 22;4(2):248-59
pubmed: 24957025
Pharmacogenet Genomics. 2005 May;15(5):311-9
pubmed: 15864132
Metabolism. 2010 Feb;59(2):299-304
pubmed: 19796777
J Nutr. 2012 May;142(5):824-31
pubmed: 22457394
Eur J Nutr. 2016 Jun;55(4):1535-44
pubmed: 26130326
Obesity (Silver Spring). 2015 Jan;23(1):28-31
pubmed: 25294800
Stroke. 2008 Jul;39(7):1932-7
pubmed: 18451345
Eur J Nutr. 2017 Aug;56(5):1931-1938
pubmed: 27271094
Arch Intern Med. 2009 Nov 9;169(20):1897-906
pubmed: 19901143
Curr Opin Genet Dev. 2018 Jun;50:86-95
pubmed: 29529423
Nat Genet. 2010 Aug;42(8):684-7
pubmed: 20657596
J Clin Invest. 2011 Jun;121(6):2111-7
pubmed: 21633179
Free Radic Res. 2013 Oct;47(10):781-92
pubmed: 23952573
Mol Aspects Med. 2018 Oct;63:18-29
pubmed: 29559224