Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury.
Animals
Cell Movement
/ genetics
Flow Cytometry
Fluorescent Antibody Technique
In Situ Hybridization
Insulin-Like Growth Factor I
/ metabolism
Mice
Microglia
/ cytology
Microscopy, Confocal
Microscopy, Immunoelectron
Neurons
/ metabolism
Oligodendroglia
/ metabolism
Spinal Cord Injuries
/ metabolism
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
31 01 2019
31 01 2019
Historique:
received:
13
08
2018
accepted:
08
01
2019
entrez:
2
2
2019
pubmed:
2
2
2019
medline:
9
4
2019
Statut:
epublish
Résumé
The role of microglia in spinal cord injury (SCI) remains poorly understood and is often confused with the response of macrophages. Here, we use specific transgenic mouse lines and depleting agents to understand the response of microglia after SCI. We find that microglia are highly dynamic and proliferate extensively during the first two weeks, accumulating around the lesion. There, activated microglia position themselves at the interface between infiltrating leukocytes and astrocytes, which proliferate and form a scar in response to microglia-derived factors, such as IGF-1. Depletion of microglia after SCI causes disruption of glial scar formation, enhances parenchymal immune infiltrates, reduces neuronal and oligodendrocyte survival, and impairs locomotor recovery. Conversely, increased microglial proliferation, induced by local M-CSF delivery, reduces lesion size and enhances functional recovery. Altogether, our results identify microglia as a key cellular component of the scar that develops after SCI to protect neural tissue.
Identifiants
pubmed: 30705270
doi: 10.1038/s41467-019-08446-0
pii: 10.1038/s41467-019-08446-0
pmc: PMC6355913
doi:
Substances chimiques
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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