Efficacy of high-affinity liposomal astaxanthin on up-regulation of age-related markers induced by oxidative stress in human corneal epithelial cells.
age-related markers
astaxanthin
desiccation stress
dry eye
liposomes
Journal
Journal of clinical biochemistry and nutrition
ISSN: 0912-0009
Titre abrégé: J Clin Biochem Nutr
Pays: Japan
ID NLM: 8700907
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
21
02
2018
accepted:
28
03
2018
entrez:
2
2
2019
pubmed:
2
2
2019
medline:
2
2
2019
Statut:
ppublish
Résumé
Decreases in tear volume, unstable tear films and excessive tear evaporation are known to cause desiccation and hyperosmolar stress. These, in turn, induce oxidative stress that is thought to cause dry eye, which is also considered to be age-related disease. We hypothesized that oxidative stress induces up-regulation of age-related markers, and that the antioxidant astaxanthin prepared as a liposomal formulation may be a candidate for the treatment of dry eye. Herein, we examined age-related markers in an
Identifiants
pubmed: 30705509
doi: 10.3164/jcbn.18-27
pii: jcbn18-27
pmc: PMC6348414
doi:
Types de publication
Journal Article
Langues
eng
Pagination
27-35Déclaration de conflit d'intérêts
The authors report no actual or potential conflict of interest, including any financial, personal or other relationships with other people or organizations within three years of beginning the submitted work that could inappropriately influence, or be perceived to influence, our work.
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