5-Aminolevulinic acid with ferrous iron improves early renal damage and hepatic steatosis in high fat diet-induced obese mice.
5-aminolevulinic acid
diabetic nephropathy
heme oxygenase-1
hepatic steatosis
high fat diet
Journal
Journal of clinical biochemistry and nutrition
ISSN: 0912-0009
Titre abrégé: J Clin Biochem Nutr
Pays: Japan
ID NLM: 8700907
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
15
03
2018
accepted:
11
06
2018
entrez:
2
2
2019
pubmed:
2
2
2019
medline:
2
2
2019
Statut:
ppublish
Résumé
5-Aminolevulinic acid, a natural amino acid, activates mitochondrial respiration and induces heme oxygenase-1 expression. Obesity and type 2 diabetes mellitus are associated with age-related mitochondrial respiration defect, oxidative stress and inflammation. The aim of this study is to investigate the effects of 5-aminolevulinic acid with sodium ferrous citrate on early renal damage and hepatic steatosis. 7-Month-old C57BL/6 mice were fed with a standard diet or high fat diet for 9 weeks, which were orally administered 300 mg/kg 5-aminolevulinic acid combined with 47 mg/kg sodium ferrous citrate (5-aminolevulinic acid/sodium ferrous citrate) or vehicle for the last 5 weeks. We observed that 5-aminolevulinic acid/sodium ferrous citrate significantly decreased body weight, fat weight, hepatic lipid deposits and improved levels of blood glucose and oral glucose tolerance test. In addition, 5-aminolevulinic acid/sodium ferrous citrate suppressed increased glomerular tuft area in high fat diet-fed mice, which was associated with increased heme oxygenase-1 protein expression. Our findings demonstrate additional evidence that 5-aminolevulinic acid/sodium ferrous citrate could improve glucose and lipid metabolism in diabetic mice. 5-Aminolevulinic acid/sodium ferrous citrate has potential application in obesity or type 2 diabetes mellitus-associated disease such as diabetic nephropathy and nonalcoholic fatty liver disease.
Identifiants
pubmed: 30705513
doi: 10.3164/jcbn.18-35
pii: jcbn18-35
pmc: PMC6348406
doi:
Types de publication
Journal Article
Langues
eng
Pagination
59-65Déclaration de conflit d'intérêts
The authors declare that they have no competing interest. A. Kamiya, T. Hara, Y. Kuroda, U. Ota, M. Ishizuka, M. Nakajima, T. Tanaka are employees of SBI Pharmaceuticals Co., Ltd.
Références
FASEB J. 2000 Mar;14(3):439-47
pubmed: 10698958
Proc Nutr Soc. 2000 Aug;59(3):359-71
pubmed: 10997652
J Inorg Biochem. 2000 Nov;82(1-4):33-41
pubmed: 11132636
Exp Clin Endocrinol Diabetes. 2001;109(3):127-34
pubmed: 11409293
Diabetologia. 2001 Aug;44(8):946-65
pubmed: 11484071
JAMA. 2003 Jan 1;289(1):76-9
pubmed: 12503980
Biochem J. 1956 Sep;64(1):80-90
pubmed: 13363809
Biochem J. 1956 Sep;64(1):90-100
pubmed: 13363810
Free Radic Biol Med. 2003 Dec 1;35(11):1491-9
pubmed: 14642397
Biofactors. 2004;20(1):49-59
pubmed: 15096660
Gastroenterology. 2007 May;132(6):2169-80
pubmed: 17498510
Am J Physiol Renal Physiol. 2009 Jan;296(1):F118-26
pubmed: 18971213
Circulation. 2010 Jan 19;121(2):230-6
pubmed: 20038741
Int Immunopharmacol. 2011 Mar;11(3):358-65
pubmed: 21144919
Diabetes. 2011 Feb;60(2):634-43
pubmed: 21270273
Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E1047-58
pubmed: 21386058
BMC Res Notes. 2011 Mar 17;4:66
pubmed: 21414200
Am J Physiol Renal Physiol. 2012 Apr 1;302(7):F791-800
pubmed: 22205229
Diabetologia. 2012 May;55(5):1535-43
pubmed: 22311417
Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10528-33
pubmed: 22689997
Clin Transl Sci. 2012 Aug;5(4):314-20
pubmed: 22883608
Circulation. 2012 Dec 18;126(25):2983-9
pubmed: 23151344
Diabetol Metab Syndr. 2013 Jan 16;5(1):3
pubmed: 23321053
Nutrition. 2013 Jul-Aug;29(7-8):1030-6
pubmed: 23759263
Am J Physiol Renal Physiol. 2013 Oct 15;305(8):F1149-57
pubmed: 23904222
PLoS One. 2013 Dec 06;8(12):e80850
pubmed: 24324635
Int Immunopharmacol. 2014 Apr;19(2):300-7
pubmed: 24530569
Nutr Res. 2014 Jun;34(6):544-51
pubmed: 25026922
Am J Physiol Cell Physiol. 2015 Apr 15;308(8):C665-72
pubmed: 25652453
Invest Ophthalmol Vis Sci. 2015 May;56(5):3095-102
pubmed: 25813998
J Clin Biochem Nutr. 2015 Sep;57(2):145-50
pubmed: 26388673
Biochem Biophys Res Commun. 2016 Feb 19;470(4):900-6
pubmed: 26820535
Antioxid Redox Signal. 2016 Oct 20;25(12):657-684
pubmed: 26906673
Cell J. 2016 Spring;18(1):97-102
pubmed: 27054124
FEBS Open Bio. 2016 Apr 29;6(6):515-28
pubmed: 27239432
Metabolism. 2016 Aug;65(8):1183-95
pubmed: 27301803
Cell Rep. 2016 Sep 13;16(11):2991-3002
pubmed: 27626667
J Diabetes Res. 2016;2016:8294805
pubmed: 27738640
BMC Pharmacol Toxicol. 2017 Jan 30;18(1):7
pubmed: 28132645
Prog Mol Biol Transl Sci. 2017;146:13-46
pubmed: 28253984
Nat Rev Gastroenterol Hepatol. 2017 Jun;14(6):343-355
pubmed: 28428634
Sci Rep. 2017 Jun 21;7(1):4013
pubmed: 28638045
J Biomed Sci. 2017 Jul 27;24(1):50
pubmed: 28750629
Biochem Biophys Rep. 2017 Jul 13;11:105-111
pubmed: 28955775
Nephrology (Carlton). 2019 Jan;24(1):28-38
pubmed: 29068550