Chronic Kidney Disease Is Linked to Carotid Nodular Calcification, An Unstable Plaque Not Correlated to Inflammation.
carotid
chronic kidney disease
histopathology
nodular calcification
Journal
Aging and disease
ISSN: 2152-5250
Titre abrégé: Aging Dis
Pays: United States
ID NLM: 101540533
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
08
11
2017
accepted:
17
01
2018
entrez:
2
2
2019
pubmed:
2
2
2019
medline:
2
2
2019
Statut:
epublish
Résumé
The incidence and the different type of carotid calcifications, nodular and non-nodular, and their role in the acute cerebrovascular disease has not yet been defined. Various studies have correlated the presence of specific risk factors, in particular the chronic kidney disease, with the presence of calcification, but not with the type of calcification. Since it is likely that carotid nodular calcifications rather than those with non-nodular aspect may represent a plaque at high risk of rupture, the purpose of our study was to evaluate the role of nodular calcification in the pathogenesis of cerebrovascular syndromes and their possible correlation with specific risk factors. A total of 168 carotid plaques from symptomatic and asymptomatic patients submitted to endarterectomy, whom complete clinical and laboratory assessment of major cardiovascular risk factors was available, were studied. In 21 endarterectomies (5 from symptomatic and 16 from asymptomatic patients) an eruptive calcified nodule, consisting of calcified plates associated to a small amount of fibrous tissue without extracellular lipids and inflammatory cells, was found protruding into the lumen. Nodular calcifications were significantly observed in patients affected by chronic kidney disease (with GFR<60 ml / min / 1.73 m
Identifiants
pubmed: 30705769
doi: 10.14336/AD.2018.0117
pii: ad-10-1-71
pmc: PMC6345328
doi:
Types de publication
Journal Article
Langues
eng
Pagination
71-81Déclaration de conflit d'intérêts
Conflicts of interest All submitting authors, Marina Cardellini, Valentina Rovella, Manuel Scimeca, Lucia Anemona, Simone Bischetti, Sara Casella, Andrea Saggini, Elena Bonanno, Marta Ballanti, Francesca Davato, Rossella Menghini, Arnaldo Ippoliti, Giuseppe Santeusanio, Nicola Di Daniele, Massimo Federici and Alessandro Mauriello, have no conflict of interest to declare.
Références
Arterioscler Thromb Vasc Biol. 2000 May;20(5):1262-75
pubmed: 10807742
N Engl J Med. 2000 May 18;342(20):1478-83
pubmed: 10816185
Arterioscler Thromb Vasc Biol. 2001 Oct;21(10):1618-22
pubmed: 11597935
Hypertension. 2001 Oct;38(4):938-42
pubmed: 11641313
Stroke. 2002 May;33(5):1214-9
pubmed: 11988593
Circulation. 2002 Dec 17;106(25):3143-421
pubmed: 12485966
Nephrol Dial Transplant. 2003 Sep;18(9):1731-40
pubmed: 12937218
Circ Res. 2004 Sep 17;95(6):560-7
pubmed: 15375022
JAMA. 2004 Oct 20;292(15):1845-52
pubmed: 15494582
Lab Invest. 2005 Jan;85(1):9-23
pubmed: 15568038
AJR Am J Roentgenol. 2006 Feb;186(2):547-52
pubmed: 16423966
Circulation. 2006 May 16;113(19):2320-8
pubmed: 16651471
Neurosurgery. 2006 Nov;59(5 Suppl 3):S219-27; discussion S3-13
pubmed: 17053606
Circ Res. 2006 Nov 10;99(10):1044-59
pubmed: 17095733
Semin Dial. 2007 Mar-Apr;20(2):134-8
pubmed: 17374087
Circulation. 2007 Dec 11;116(24):2841-50
pubmed: 18040026
Cardiovasc Pathol. 2008 Mar-Apr;17(2):117-23
pubmed: 18329558
Nat Clin Pract Cardiovasc Med. 2009 Jan;6(1):16-26
pubmed: 19029993
Cerebrovasc Dis. 2009;27(2):193-200
pubmed: 19136823
J Hum Hypertens. 2010 Feb;24(2):86-92
pubmed: 19494836
Atherosclerosis. 2010 Feb;208(2):572-80
pubmed: 19683236
Nat Rev Cardiol. 2009 Nov;6(11):681-8
pubmed: 19786983
J Vasc Surg. 2010 Apr;51(4):1015-25
pubmed: 20045615
J Am Soc Nephrol. 2010 Apr;21(4):689-96
pubmed: 20203159
J Am Coll Cardiol. 2010 Nov 9;56(20):1613-22
pubmed: 21050970
Nat Immunol. 2011 Mar;12(3):204-12
pubmed: 21321594
Lancet. 2012 Jan 14;379(9811):165-80
pubmed: 21840587
Am J Cardiol. 2011 Dec 1;108(11):1547-51
pubmed: 21872195
Circ Res. 2011 Sep 2;109(6):697-711
pubmed: 21885837
Int J Cardiol. 2012 Mar 8;155(2):309-11
pubmed: 22192293
Circulation. 2012 Jul 31;126(5):537-45
pubmed: 22744975
Atherosclerosis. 2012 Oct;224(2):340-7
pubmed: 22877867
Atherosclerosis. 2013 Jul;229(1):124-9
pubmed: 23578355
Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1753-8
pubmed: 23766262
Cardiovasc Res. 2013 Dec 1;100(3):472-80
pubmed: 23975852
Stroke. 2013 Nov;44(11):3071-7
pubmed: 23988640
Circulation. 2014 Jun 24;129(25 Suppl 2):S1-45
pubmed: 24222016
Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):715-23
pubmed: 24665125
Eur Heart J. 2014 Jun 14;35(23):1515-25
pubmed: 24740885
World J Cardiol. 2014 Apr 26;6(4):115-29
pubmed: 24772252
Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1329-32
pubmed: 24876349
Circ Res. 2014 Jun 6;114(12):1852-66
pubmed: 24902970
Acta Cardiol. 2014 Jun;69(3):316-8
pubmed: 25029880
J Clin Lipidol. 2014 Nov-Dec;8(6 Suppl):S1-36
pubmed: 25523435
Cell Mol Life Sci. 2015 Jul;72(13):2475-89
pubmed: 25746430
Curr Osteoporos Rep. 2015 Aug;13(4):206-15
pubmed: 25947259
Aging (Albany NY). 2015 Apr;7(4):269-79
pubmed: 26131456
J Am Coll Cardiol. 2015 Oct 13;66(15):1643-53
pubmed: 26449133
Cell Death Dis. 2015 Nov 12;6:e1974
pubmed: 26561783
J Nat Sci Biol Med. 2015 Aug;6(Suppl 1):S1-6
pubmed: 26604593
J Am Coll Cardiol. 2016 Jan 5;67(1):69-78
pubmed: 26764069
Circ Res. 2016 Feb 19;118(4):653-67
pubmed: 26892964
Circ Res. 2016 Feb 19;118(4):668-78
pubmed: 26892965
Clin Chem. 1972 Jun;18(6):499-502
pubmed: 4337382
J Am Coll Cardiol. 1998 Jan;31(1):126-33
pubmed: 9426030