Intracranial Aneurysms in Sickle Cell Disease.
Intracranial aneurysm
growth
risk factors
rupture
sickle-cell disease
subarachnoid hemorrhage.
Journal
Current neurovascular research
ISSN: 1875-5739
Titre abrégé: Curr Neurovasc Res
Pays: United Arab Emirates
ID NLM: 101208439
Informations de publication
Date de publication:
2019
2019
Historique:
received:
01
01
2019
revised:
16
01
2019
accepted:
21
01
2019
pubmed:
2
2
2019
medline:
31
3
2020
entrez:
2
2
2019
Statut:
ppublish
Résumé
The exact causes of intracranial aneurysms (IAs) are still unknown. However, certain diseases are known to be associated with IAs. To analyze the differences in IA characteristics in the general population and in individuals with sickle-cell disease (SCD). We systematically searched PubMed, Scopus, Web of Science, and Cochrane Library for Data on SCD patients with IAs. We compared IA characteristics of SCD patients with those from 2451 healthy IA carriers from our observational cohort. 129 SCD patients with IAs were identified in 42 studies. The SCD patient cohort was characterized by younger age (mean 27.1 vs 54.9 years, p<0.0001) and lower female prevalence (57.7% vs 68.4%, p=0.0177). The prevalence (47% vs 34.5%, p=0.004) and the number (3.02 vs 2.56 IAs/patient, p=0.004) of multiple IAs were also higher in the SCD cohort. Unruptured IAs (3.27 vs 6.16 mm, p<0.0001), but not ruptured IAs (7.8 vs 7.34 mm, p=0.9086) were significantly smaller in the SCD cohort. In addition, IAs were more frequently located in the internal carotid artery (45% vs 29%, p<0.0001) or posterior circulation (43% vs 20%, p<0.0001). Higher age (≥30 years, p=0.007), IA size ≥7 mm (p=0.008), and location in posterior circulation (p=0.01) were independently associated with subarachnoid hemorrhage in SCD. There is a distinct demographic and radiographic pattern of IA in SCD. Risk factors for IA rupture in SCD are mostly congruent with those in healthy individuals.
Sections du résumé
BACKGROUND
The exact causes of intracranial aneurysms (IAs) are still unknown. However, certain diseases are known to be associated with IAs.
OBJECTIVE
To analyze the differences in IA characteristics in the general population and in individuals with sickle-cell disease (SCD).
METHODS
We systematically searched PubMed, Scopus, Web of Science, and Cochrane Library for Data on SCD patients with IAs. We compared IA characteristics of SCD patients with those from 2451 healthy IA carriers from our observational cohort.
RESULTS
129 SCD patients with IAs were identified in 42 studies. The SCD patient cohort was characterized by younger age (mean 27.1 vs 54.9 years, p<0.0001) and lower female prevalence (57.7% vs 68.4%, p=0.0177). The prevalence (47% vs 34.5%, p=0.004) and the number (3.02 vs 2.56 IAs/patient, p=0.004) of multiple IAs were also higher in the SCD cohort. Unruptured IAs (3.27 vs 6.16 mm, p<0.0001), but not ruptured IAs (7.8 vs 7.34 mm, p=0.9086) were significantly smaller in the SCD cohort. In addition, IAs were more frequently located in the internal carotid artery (45% vs 29%, p<0.0001) or posterior circulation (43% vs 20%, p<0.0001). Higher age (≥30 years, p=0.007), IA size ≥7 mm (p=0.008), and location in posterior circulation (p=0.01) were independently associated with subarachnoid hemorrhage in SCD.
CONCLUSION
There is a distinct demographic and radiographic pattern of IA in SCD. Risk factors for IA rupture in SCD are mostly congruent with those in healthy individuals.
Identifiants
pubmed: 30706782
pii: CNR-EPUB-96271
doi: 10.2174/1567202616666190131160847
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
63-76Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.